7212-39-7

Basic information

• Product Name: Benzenemethanol, 4-(methoxymethoxy)-
• CAS NO: 7212-39-7
• Molecular Formula: C9H12O3
• Molecular Weight: 168.192
• Mol File: 7212-39-7.mol
• Article Data: 13

Chemical Properties

• CAS DataBase Reference: Benzenemethanol, 4-(methoxymethoxy)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenemethanol, 4-(methoxymethoxy)-(7212-39-7)
• EPA Substance Registry System: Benzenemethanol, 4-(methoxymethoxy)-(7212-39-7)

Safety Data

• Hazardous Substances Data: 7212-39-7(Hazardous Substances Data)

Usage

Chemical structure

Consists of a benzene ring with a hydroxyl group and two methoxy groups attached at the para position

Main properties

Aromatic and aliphatic properties, used in fragrances, pharmaceuticals, plastic manufacturing

Uses

Production of fragrances, pharmaceuticals, stabilizer in plastic manufacturing, precursor in organic compound synthesis

Role

Plays a role in the development of novel materials with specialized properties

Upstream product

• 123-08-0 4-hydroxy-benzaldehyde 
• 107-30-2 chloromethyl methyl ether 
• 67-64-1 acetone 
• 6515-21-5 4-methoxymethoxy-benzaldehyde 

Downstream Products

• 250602-88-1 [4-(methoxymethoxy)benzyloxy]amine 
• 1353178-34-3 C₁₁H₁₆O₃S 
• 1353178-35-4 C₂₁H₃₂O₄S 
• 1353178-33-2 4-(methoxymethoxy)benzyl methyl ether 
• 1417423-56-3 4-(2,4,6-trimethoxybenzyl)phenol 
• 1417423-59-6 2-(4-hydroxybenzyl)-4,5-dimethoxyphenol 
• 1417423-60-9 4-((6-methoxybenzo[d][1,3]dioxol-5-yl)methyl)phenol 
• 1417423-61-0 4-(4-hydroxybenzyl)naphthalen-1-ol 
• 1417423-62-1 4-((2-methoxynaphthalen-1-yl)methyl)phenol 
• 1417423-63-2 4-(benzofuran-3-ylmethyl)phenol 
• 1417423-64-3 4-(2,4,6-trimethylbenzyl)phenol 
• 1417423-53-0 4-(methoxylmethoxy)benzyl acetate 
• 250602-89-2 methyl (E)-4-[(4-hydroxybenzyloxy)imino]-4-phenylbutyrate 

Relevant articles and documents

Discovery of novel 3-butyl-6-benzyloxyphthalide Mannich base derivatives as multifunctional agents against Alzheimer's disease

Based on the multitarget-directed ligands strategy, a series of 3-butyl-6-benzyloxyphthalide Mannich base derivatives were designed, synthesized and identified for Alzheimer's disease (AD). Biological activity studies demonstrated that the designed hybrid

Synthesis and Pharmacological Characterization of Conformationally Restricted Retigabine Analogues as Novel Neuronal Kv7 Channel Activators

Kv7 K+ channels represent attractive pharmacological targets for the treatment of different neurological disorders, including epilepsy. In this paper, 42 conformationally restricted analogues of the prototypical Kv7 activator retigabine have been synthesized and tested by electrophysiological patch-clamp experiments as Kv7 agonists. When compared to retigabine (0.93 ± 0.43 μM), the EC50s for Kv7.2 current enhancements by compound 23a (0.08 ± 0.04 μM) were lower, whereas no change in potency was observed for 24a (0.63 ± 0.07 μM). In addition, compared to retigabine, 23a and 24a showed also higher potency in activating heteromeric Kv7.2/Kv7.3 and homomeric Kv7.4 channels. Molecular modeling studies provided new insights into the chemical features required for optimal interaction at the binding site. Stability studies evidenced improved chemical stability of 23a and 24a in comparison with retigabine. Overall, the present results highlight that the N5-alkylamidoindole moiety provides a suitable pharmacophoric scaffold for the design of chemically stable, highly potent and selective Kv7 agonists.

A Modular Access to (±)-Tubocurine and (±)-Curine - Formal Total Synthesis of Tubocurarine

Two consecutive Cu-catalyzed Ullmann-type C-O couplings permitted the first successful entry toward the curare alkaloids (±)-tubocurine and (±)-curine. Starting from vanillin, the synthetic sequence comprises 15 linear steps and includes a total of 24 transformations. In addition, the total synthesis of tubocurine represents a formal total synthesis of the famous arrow poison alkaloid tubocurarine.