721402-02-4

Usage

Uses

Used in Pharmaceutical Industry:
4-BROMO-1,5-DIMETHYL-3-(TRIFLUOROMETHYL)-1H-PYRAZOLE is used as a key intermediate in the synthesis of various pharmaceutical compounds. Its bromine and trifluoromethyl groups enable the introduction of these functional groups into organic molecules, which can enhance the biological activity and pharmacological properties of the resulting compounds.
Used in Agrochemical Industry:
In the agrochemical industry, 4-BROMO-1,5-DIMETHYL-3-(TRIFLUOROMETHYL)-1H-PYRAZOLE serves as a valuable building block for the development of new agrochemicals. Its ability to introduce bromine and trifluoromethyl groups into organic molecules can improve the efficacy and selectivity of agrochemical products.
Used in Organic Synthesis:
4-BROMO-1,5-DIMETHYL-3-(TRIFLUOROMETHYL)-1H-PYRAZOLE is used as a versatile reagent in organic synthesis for the functionalization of aromatic compounds. Its bromine and trifluoromethyl groups can be utilized for various synthetic transformations, making it an important compound in the field of synthetic chemistry.
Used in the Synthesis of Other Organic Compounds:
Beyond its applications in pharmaceuticals and agrochemicals, 4-BROMO-1,5-DIMETHYL-3-(TRIFLUOROMETHYL)-1H-PYRAZOLE is also used in the synthesis of other organic compounds. Its unique structure and properties make it a valuable building block for the development of novel organic molecules with potential applications in various industries.

InChI:InChI=1/C6H6BrF3N2/c1-3-4(7)5(6(8,9)10)11-12(3)2/h1-2H3

Upstream product

• 60061-68-9 4-bromo-5-methyl-3-(trifluoromethyl)-1H-pyrazole 
• 74-88-4 methyl iodide 
• 79080-31-2 1,5-dimethyl-3-(trifluoromethyl)pyrazole 
• 10010-93-2 5-methyl-3-trifluoromethyl-1H-pyrazole 
• 367-57-7 1,1,1-Trifluoro-2,4-pentanedione 

Downstream Products

• 1082065-80-2 1,5-dimethyl-3-(trifluoromethyl)-1H-pyrazole-4-carbaldehyde 

Relevant academic research and scientific papers

COMPOUNDS AND THEIR USE AS INHIBITORS OF N-MYRISTOYL TRANSFERASE

This invention provides compounds of formula (I) and salts thereof, which have activity as inhibitors of N-myristoyl transferase (NMT). The invention also relates to uses of such compounds as medicaments, in particular in the treatment of a disease or disorder in which inhibition of N-myristoyl transferase provides a therapeutic or prophylactic effect, including protozoan infections (such as malaria and leishmaniasis), viral infections (such as human rhinovirus and HIV), and hyperproliferative disorders (such as B-cell lymphoma).

SOLUBLE GUANYLATE CYCLASE ACTIVATORS

The invention relates to compounds having the structure of Formula (I) and pharmaceutically acceptable salts thereof, which are soluble guanylate cyclase activators. The compounds are capable of modulating the body's production of cyclic guanosine monophosphate ("cGMP") and are generally suitable for the therapy and prophylaxis of diseases which are associated with a disturbed cGMP balance. The compounds are useful for treatment or prevention of cardiovascular diseases, endothelial dysfunction, diastolic dysfunction, atherosclerosis, hypertension, pulmonary hypertension, angina pectoris, thromboses, restenosis, myocardial infarction, strokes, cardiac insufficiency, pulmonary hypertonia, erectile dysfunction, asthma bronchiale, chronic kidney insufficiency, diabetes, or cirrhosis of the liver.

2-[4-(PYRAZOL-4-YLALKYL)PIPERAZIN-1-YL]-3-PHENYL PYRAZINES AND PYRIDINES AND 3-[4-(PYRAZOL-4-YLALKYL)PIPERAZIN-1-YL]-2-PHENYL PYRIDINES AS 5-HT7 RECEPTOR ANTAGONISTS

The present invention provides selective 5-HT7 receptor antagonist compounds of Formula I and their use in the treatment of migraine, persistent pain, and anxiety: where A and B are each independently C(H)= or N=, provided that at least one of A and B is -N=, n is 1-3, m is 0-3, and R14 are as defined herein.

Synthesis of novel 1,4,5-trisubstituted 3-trifluoromethylpyrazoles via microwave-assisted Stille coupling reactions

1,5-Disubstituted 3-trifluoromethylpyrazoles were reacted with N-bromosuccinimide in DMF at room temperature or 70-80 °C for 1-2 h to afford the corresponding 4-bromo-substituted pyrazoles 2 in 95-99% yields. The microwave-assisted Stille coupling reactio

Pyrazolylarylalkines

The present invention relates to pyrazolylarylalkines and to their use, to a process for preparing pyrazolylarylalkines and also to intermediates.