79080-31-2

Usage

Uses

Used in Pharmaceutical Industry:
1,5-DIMETHYL-3-(TRIFLUOROMETHYL)-1H-PYRAZOLE is used as a building block or intermediate for the synthesis of various pharmaceuticals. Its unique structure and properties make it a valuable component in the development of new drugs with potential therapeutic applications.
Used in Agrochemical Industry:
In the agrochemical industry, 1,5-DIMETHYL-3-(TRIFLUOROMETHYL)-1H-PYRAZOLE serves as an intermediate in the synthesis of agrochemicals. Its incorporation into these products can enhance their effectiveness in agricultural applications, such as pest control and crop protection.
Used in Neurological Disorder Research:
1,5-DIMETHYL-3-(TRIFLUOROMETHYL)-1H-PYRAZOLE is used as a GABA(A) receptor modulator in the research and development of new drugs for neurological disorders. Its ability to modulate these receptors could lead to the creation of innovative treatments for conditions such as epilepsy, anxiety, and insomnia.
Used in Controlled Laboratory Settings:
Due to its high reactivity, 1,5-DIMETHYL-3-(TRIFLUOROMETHYL)-1H-PYRAZOLE is used in controlled laboratory settings for various chemical reactions and experiments. Its careful handling and use in these environments ensure the safety of researchers and the integrity of the chemical processes involved.

InChI:InChI=1/C4H4F4/c1-3(5)2-4(6,7)8/h2H,1H3/b3-2+

Upstream product

• 367-57-7 1,1,1-Trifluoro-2,4-pentanedione 
• 60-34-4 methylhydrazine 
• 135351-20-1 1,1,1-trifluoro-4-methoxypent-3-en-2-one 
• 1634-04-4 tert-butyl methyl ether 
• 116-11-0 2-Methoxypropene 
• 407-25-0 trifluoroacetic anhydride 
• 10010-93-2 5-methyl-3-trifluoromethyl-1H-pyrazole 
• 74-88-4 methyl iodide 

Downstream Products

• 721402-02-4 4-bromo-1,5-dimethyl-3-(trifluoromethyl)-1H-pyrazole 
• 88398-42-9 1,5-dimethyl-3-(trifluoromethyl)-1H-pyrazole-4-sulfonyl chloride 
• 128694-63-3 1-methyl-3-(trifluoromethyl)pyrazole-5-carboxylic acid 

Relevant academic research and scientific papers

Ambident polyfluoroalkyl-substituted pyrazoles in the methylation reactions

The reactivity of polyfluoroalkyl-containing pyrazoles has been estimated using the quantum chemical calculations. A good regioselectivity in the methylation of polyfluoroalkylpyrazoles was reached while varying the reaction conditions. Under basic condit

SUBSTITUTED PYRIDINE AND PYRAZINE BMI-1 INHIBITORS

Amine substituted pyridine and pyrazine compounds and forms thereof that inhibit the function and reduce the level of B -cell specific Moloney murine leukemia virus integration site 1 (Bmi-1) protein and methods for their use to inhibit Bmi-1 function and reduce the level of Bmi-1 to treat a cancer mediated by Bmi-1 are described herein.

THERAPEUTIC COMPOUNDS

The present invention provides compounds of formula (I) and pharmaceutically acceptable salts thereof in which m, n, W, X, Y, Z, R, R1, R2, R3 and R4 are as defined in the specification, for use in therapy.

SULFONYL PIPERIDINE DERIVATIVES AND THEIR USE FOR TREATING PROKINETICIN MEDIATED DISEASES

The present invention provides compounds of formula (I) and pharmaceutically acceptable salts thereof : (I) in which m, n, W, X, Y, Z, R1, R2, R3 and R4 are as defined in the specification, for use in the treatm

SOLUBLE GUANYLATE CYCLASE ACTIVATORS

The invention relates to compounds having the structure of Formula (I) and pharmaceutically acceptable salts thereof, which are soluble guanylate cyclase activators. The compounds are capable of modulating the body's production of cyclic guanosine monophosphate ("cGMP") and are generally suitable for the therapy and prophylaxis of diseases which are associated with a disturbed cGMP balance. The compounds are useful for treatment or prevention of cardiovascular diseases, endothelial dysfunction, diastolic dysfunction, atherosclerosis, hypertension, pulmonary hypertension, angina pectoris, thromboses, restenosis, myocardial infarction, strokes, cardiac insufficiency, pulmonary hypertonia, erectile dysfunction, asthma bronchiale, chronic kidney insufficiency, diabetes, or cirrhosis of the liver.

Improved regioselectivity in pyrazole formation through the use of fluorinated alcohols as solvents: Synthesis and biological activity of fluorinated tebufenpyrad analogs

(Chemical Equation Presented) The preparation of N-methylpyrazoles is usually accomplished through reaction of a suitable 1,3-diketone with methylhydrazine in ethanol as the solvent. This strategy, however, leads to the formation of regioisomeric mixtures of N-methylpyrazoles, which sometimes are difficult to separate. We have determined that the use of fluorinated alcohols such as 2,2,2-trifluoroethanol (TFE) and 1,1,1,3,3,3-hexafluoro-2-propanol (HFIP) as solvents dramatically increases the regioselectivity in the pyrazole formation, and we have used this modification in a straightforward synthesis of fluorinated analogs of Tebufenpyrad with acaricide activity.

NOVEL HERBICIDES

Compounds of formula I: wherein R1, R2, R3, R4, m, R5, R6, n and Y are as defined in claim 1; or N-oxides, salts and optical isomers thereof. Furthermore, the present invention relates to processes for preparing compounds of formula (I), to herbicidal compositions comprising them and to methods of using them to control plants or to inhibit plant growth.

Pyrazolylarylalkines

The present invention relates to pyrazolylarylalkines and to their use, to a process for preparing pyrazolylarylalkines and also to intermediates.

Pyrazolylalkines

The present invention relates to pyrazolyalkines and to their use, to a process for preparing them and also to intermediates.

Synthesis of Some Trifluoromethyl Substituted 1-Methylpyrazoles

The major products from the reaction of β-alkoxyvinyl trifluoromethyl ketones 1a-c with methylhydrazine (2) in absolute ethanol are the 3-(trifluoromethyl)-substituted-1-methylpyrazoles 3a-3c with lesser amounts of the 5-(trifluoromethyl)-substituted prod