72141-44-7

Usage

Uses

Used in Chemical Synthesis:
4-Chloro-2-methoxy-pyridine is used as a reagent for the preparation of cyclopalladated ferrocenylimines. These ferrocenylimines serve as efficient catalysts in the synthesis of arylboronate esters, which are important intermediates in organic chemistry and have applications in the production of pharmaceuticals, agrochemicals, and advanced materials.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 4-chloro-2-methoxy-pyridine is utilized as a key intermediate in the synthesis of various drug molecules. Its unique structure allows for further functionalization and modification, making it a versatile building block for the development of new therapeutic agents.
Used in Catalyst Development:
4-Chloro-2-methoxy-pyridine is also used in the development of novel catalysts for various chemical reactions. Its presence in cyclopalladated ferrocenylimines enhances the catalytic activity and selectivity of these catalysts, leading to improved reaction efficiency and reduced environmental impact.

InChI:InChI=1/C6H6ClNO/c1-9-6-4-5(7)2-3-8-6/h2-4H,1H3

Upstream product

• 98197-72-9 (2-iodo-pyridin-4-yl)-dimethyl-amine 
• 26452-80-2 2,4-dichloropyridine 
• 124-41-4 sodium methylate 
• 40673-25-4 4-chloro-2-hydroxypyridine 
• 74-88-4 methyl iodide 
• 851607-23-3 2-methoxy-pyridin-4-ylmagnesium chloride 

Downstream Products

• 1312350-29-0 (3R,4S)-N-[3-bromo-5-(3-methoxypropyl)-4-methylbenzyl]-N-cyclopropyl-4-(1-methyl-2-oxo-1,2-dihydropyridin-4-yl)-piperidine-3-carboxamide 
• 1312350-23-4 (3R,4S)-1-(tert-butoxycarbonyl)-4-(1-methyl-2-oxo-1,2-dihydropyridin-4-yl)piperidine-3-carboxylic acid 
• 1312350-26-7 tert-butyl (3R,4S)-3-{[[3-bromo-5-(3-methoxypropyl)-4-methylbenzyl](cyclopropyl)amino]carbonyl}-4-(1-methyl-2-oxo-1,2-dihydropyridin-4-yl)piperidine-1-carboxylate 
• 1312350-32-5 (3R,4S)-N-[3-bromo-5-(3-methoxypropyl)-4-methylbenzyl]-N-cyclopropyl-4-(1-methyl-2-oxo-1,2-dihydropyridin-4-yl)-piperidine-3-carboxamide hydrochloride 
• 1008451-58-8 4-chloro-2-methoxynicotinic aldehyde 

Relevant academic research and scientific papers

Novel synthesis method for ortho-alkane superseded pyridine

The invention relates to a novel synthesis method for ortho-alkane superseded pyridine. According to the method, ortho halogenated pyridine serves as raw materials, the ortho halogenated pyridine and corresponding alcohol react to obtain the ortho-alkane superseded pyridine under the action of sodium hydroxide. The reaction has universality for the ortho halogenated pyridine, and the method is simple and practical. Influence of consumption of the sodium hydroxide on mono-substitution and di-substitution in the reaction is inspected, alkoxy mono-substitution products and alkoxy di-substitution production are acquired, and a novel simply-operated, economical and favorable process for synthesis ortho-alkane superseded pyridine is provided.

ANTI-FIBROTIC PYRIDINONES

This application relates to polycyclic compounds with a pyridinone or pyridinone derivative core including, substituted pyridinones, 5,6- and 6,6- bicyclic heterocycles and substituted pyridine-thiones. This application also discloses methods of preparing these polycyclic compounds, pharmaceutical compositions and medicaments comprising said compounds and methods to treat, prevent or diagnose diseases, disorders or conditions associated with fibrosis.

ANTI-FIBROTIC PYRIDINONES

Disclosed are pyridinone compounds, method for preparing these compounds, and methods for treating fibrotic disorders.

Convergent kilo-scale synthesis of a potent renin inhibitor for the treatment of hypertension

Process research and development of a synthetic route towards a novel renin inhibitor (1) is described. The highly convergent synthetic route provided 1 in 15% yield on multikilogram scale with a longest linear sequence of 11 steps. The use of catalytic h

AZETIDINES AND CYCLOBUTANES AS HISTAMINE H3 RECEPTOR ANTAGONISTS

The invention relates to compounds of formula (I) wherein R, R0, R1, m, n and X1 to X4 have the meaning as cited in the description and the claims. Said compounds are useful as Histamine H3 receptor antagonists. The invention also relates to pharmaceutical compositions, the preparation of such compounds as well as the production and use as medicament.

BACTERICIDE COMPOSITION AND METHOD OF CONTROLLING PLANT DISEASE

It is to provide a fungicidal composition having stable and high fungicidal effects against cultivated crops infected with plant diseases resulting from plant diseases. A fungicidal composition containing as active ingredients (a) a benzoylpyridine derivative represented by the formula (I) or its salt: (wherein X is a halogen atom, a nitro group, a substitutable hydrocarbon group, a substitutable alkoxy group, a substitutable aryloxy group, a substitutable cycloalkoxy group, a hydroxyl group, a substitutable alkylthio group, a cyano group, a carboxyl group which may be esterified or amidated, or a substitutable amino group, n is 1, 2, 3 or 4; R1 is a substitutable alkyl group, R2' is a substitutable alkyl group, a substitutable alkoxy group, a substitutable aryloxy group, a substitutable cycloalkoxy group or a hydroxyl group, p is 1, 2 or 3, and R2" is a substitutable alkoxy group or a hydroxyl group, provided that at least two of R2' and R2" may form a condensed ring containing an oxygen atom) and (b) at least one another fungicide.

3-BENZOYL-2,4,5-SUBSTITUTED PYRIDINE DERIVATIVES OR SALTS THEREOF AND BACTERICIDES CONTAINING THE SAME

To provide 3-benzoyl-2,4,5-substituted pyridine derivatives or their salts, fungicides containing them, and intermediates for producing them. By providing a group of compounds comprising specific 3-benzoyl-2,4,5-substituted pyridine derivatives or their s