72141-44-7

Basic information

• Product Name: 4-CHLORO-2-METHOXY-PYRIDINE
• Synonyms: IFLAB-BB F2108-0069;2-METHOXY-4-CHLORO-PYRIDINE;4-CHLORO-2-METHOXY-PYRIDINE;4-chloro-methoxypridine;Pyridine, 4-chloro-2-methoxy-
• CAS NO: 72141-44-7
• Molecular Formula: C₆H₆ClNO
• Molecular Weight: 143.57
• Product Categories: Pyridine;Boronic Acid;Pyridine Series;Heterocycle-Pyridine series
• Mol File: 72141-44-7.mol
• Article Data: 7

Chemical Properties

• Melting Point: 26℃
• Boiling Point: 177℃
• Flash Point: 61℃
• Appearance: /
• Density: 1.210
• Vapor Pressure: 1.424mmHg at 25°C
• Refractive Index: 1.518
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Solubility: Chloroform (Slightly), DMSO (Slightly), Ethyl Acetate (Slightly)
• PKA: 3.66±0.10(Predicted)
• CAS DataBase Reference: 4-CHLORO-2-METHOXY-PYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-CHLORO-2-METHOXY-PYRIDINE(72141-44-7)
• EPA Substance Registry System: 4-CHLORO-2-METHOXY-PYRIDINE(72141-44-7)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 72141-44-7(Hazardous Substances Data)

Usage

Uses

4-Chloro-2-methoxypyridine is a reagent in the preparation of cyclopalladated ferrocenylimines as efficient catalysts for the preparation of arylboronate esters.

InChI:InChI=1/C6H6ClNO/c1-9-6-4-5(7)2-3-8-6/h2-4H,1H3

Upstream product

• 26452-80-2 2,4-dichloropyridine 
• 124-41-4 sodium methylate 
• 40673-25-4 4-chloro-2-hydroxypyridine 
• 74-88-4 methyl iodide 
• 98197-72-9 (2-iodo-pyridin-4-yl)-dimethyl-amine 
• 851607-23-3 2-methoxy-pyridin-4-ylmagnesium chloride 

Downstream Products

• 1312350-29-0 (3R,4S)-N-[3-bromo-5-(3-methoxypropyl)-4-methylbenzyl]-N-cyclopropyl-4-(1-methyl-2-oxo-1,2-dihydropyridin-4-yl)-piperidine-3-carboxamide 
• 1312350-23-4 (3R,4S)-1-(tert-butoxycarbonyl)-4-(1-methyl-2-oxo-1,2-dihydropyridin-4-yl)piperidine-3-carboxylic acid 
• 1312350-26-7 tert-butyl (3R,4S)-3-{[[3-bromo-5-(3-methoxypropyl)-4-methylbenzyl](cyclopropyl)amino]carbonyl}-4-(1-methyl-2-oxo-1,2-dihydropyridin-4-yl)piperidine-1-carboxylate 
• 1312350-32-5 (3R,4S)-N-[3-bromo-5-(3-methoxypropyl)-4-methylbenzyl]-N-cyclopropyl-4-(1-methyl-2-oxo-1,2-dihydropyridin-4-yl)-piperidine-3-carboxamide hydrochloride 
• 1008451-58-8 4-chloro-2-methoxynicotinic aldehyde 
• 1538625-38-5 2-methoxy-N-(2-methoxybenzyl)pyridin-4-amine 
• 408502-23-8 2-methoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine 
• 851607-27-7 5-bromo-4-chloro-2-methoxypyridine 
• 1020172-98-8 2-fluoro-4-(2-methoxypyridin-4-yloxy)benzenamine 

Relevant articles and documents

Novel synthesis method for ortho-alkane superseded pyridine

The invention relates to a novel synthesis method for ortho-alkane superseded pyridine. According to the method, ortho halogenated pyridine serves as raw materials, the ortho halogenated pyridine and corresponding alcohol react to obtain the ortho-alkane superseded pyridine under the action of sodium hydroxide. The reaction has universality for the ortho halogenated pyridine, and the method is simple and practical. Influence of consumption of the sodium hydroxide on mono-substitution and di-substitution in the reaction is inspected, alkoxy mono-substitution products and alkoxy di-substitution production are acquired, and a novel simply-operated, economical and favorable process for synthesis ortho-alkane superseded pyridine is provided.

ANTI-FIBROTIC PYRIDINONES

Disclosed are pyridinone compounds, method for preparing these compounds, and methods for treating fibrotic disorders.

AZETIDINES AND CYCLOBUTANES AS HISTAMINE H3 RECEPTOR ANTAGONISTS

The invention relates to compounds of formula (I) wherein R, R0, R1, m, n and X1 to X4 have the meaning as cited in the description and the claims. Said compounds are useful as Histamine H3 receptor antagonists. The invention also relates to pharmaceutical compositions, the preparation of such compounds as well as the production and use as medicament.