1312350-23-4

Basic information

• Product Name: 3R,4S)-1-(tert-butoxycarbonyl)-4-(1-Methyl-2-oxo-1,2-dihydropyridin-4-yl)piperidine-3-carboxylic acid
• Synonyms: 3R,4S)-1-(tert-butoxycarbonyl)-4-(1-Methyl-2-oxo-1,2-dihydropyridin-4-yl)piperidine-3-carboxylic acid
• CAS NO: 1312350-23-4
• Molecular Formula: C₁₇H₂₄N₂O₅
• Molecular Weight: 336.38
• EINECS: -0
• Mol File: 1312350-23-4.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3R,4S)-1-(tert-butoxycarbonyl)-4-(1-Methyl-2-oxo-1,2-dihydropyridin-4-yl)piperidine-3-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3R,4S)-1-(tert-butoxycarbonyl)-4-(1-Methyl-2-oxo-1,2-dihydropyridin-4-yl)piperidine-3-carboxylic acid(1312350-23-4)
• EPA Substance Registry System: 3R,4S)-1-(tert-butoxycarbonyl)-4-(1-Methyl-2-oxo-1,2-dihydropyridin-4-yl)piperidine-3-carboxylic acid(1312350-23-4)

Safety Data

• Hazardous Substances Data: 1312350-23-4(Hazardous Substances Data)

Upstream product

• 1229244-24-9 ethyl (3S,4S)-4-(1-methyl-2-oxo-1,2-dihydropyridin-4-yl)-1-(trifluoroacetyl)piperidine-3-carboxylate 
• 1229244-30-7 C₁₆H₁₉F₃N₂O₄ 
• 1229244-38-5 ethyl 2'-methoxy-1-(trifluoroacetyl)-1,2,5,6-tetrahydro-4,4'-bipyridine-3-carboxylate 
• 72141-44-7 4-chloro-2-methoxypyridine 
• 26452-80-2 2,4-dichloropyridine 
• 176525-98-7 1-(1,1-dimethylethyl) 3-ethyl 4-{[(trifluoromethyl)sulfonyl]oxy}-1,2,5,6-tetrahydropyridine-1,3-dicarboxylate 
• 98977-34-5 1-tert-butyl 3-ethyl 4-oxopiperidine-1,3-dicarboxylate 
• 1454-53-1 ethyl 1-benzyl-4-oxopiperidine-3-carboxylate hydrochloride 
• 24424-99-5 di-tert-butyl dicarbonate 
• 1315060-85-5 C₁₉H₂₈N₂O₅ 
• 1229244-21-6 1-tert-butyl 3-ethyl 2'-methoxy-5,6-dihydro-4,4'-bipyridine-1,3(2H)-dicarboxylate 
• 1194488-90-8 4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-5,6-dihydro-2H-pyridine-1,3-dicarboxylic acid 1-tert-butyl ester 3-ethyl ester 
• 100367-39-3 4-bromo-2-methoxypyridine 

Downstream Products

• 1335221-09-4 trans-N-cyclopropyl-N-({2,3-dichloro-5-[3-(methyloxy)propyl]phenyl}methyl)-4-(1-methyl-2-oxo-1,2-dihydro-4-pyridinyl)-3-piperidinecarboxamide 

Relevant articles and documents

Renin inhibitors for the treatment of hypertension: Design and optimization of a novel series of pyridone-substituted piperidines

An SAR campaign aimed at decreasing the overall lipophilicity of renin inhibitors such as 1 is described herein. It was found that replacement of the northern appendage in 1 with an N-methyl pyridone and subsequent re-optimization of the benzyl amide hand

3, 4 - SUBSTITUTED PIPERIDINE DERIVATIVES AS RENIN INHIBITORS

The present invention relates to 3,4-substituted piperidinyl-based renin inhibitor compounds bearing at 4-position oxopyridine and having the formula (I). The invention further relates to pharmaceutical compositions containing said compounds, as well as their use in treating cardiovascular events and renal insufficiency.