721450-11-9

Usage

Chlorinated derivative

A modified version of pyrrole-2-carbonyl chloride with a chlorine atom added, which can alter its chemical properties and reactivity.

Key intermediate

An essential compound in the synthesis of pyrrole-based compounds, used as a starting material for further chemical reactions.

Pharmaceutical and agrochemical industries

Commonly used in these industries for the production of various drugs and pesticides, indicating its versatility and importance in creating different products.

Highly reactive and versatile

Capable of undergoing various chemical reactions to form a wide range of derivatives with different properties and applications, making it a valuable compound in synthesis.

Unique structure and reactivity

The specific arrangement of atoms and its reactivity make it an important building block in the synthesis of biologically active compounds.

Potential health and environmental hazards

Due to its reactivity and chemical properties, it is crucial to handle 1H-Pyrrole-2-carbonyl chloride, 3-chloro- (9CI) with caution to minimize risks to human health and the environment.

Upstream product

• 1053658-09-5 3-chloro-1H-pyrrole-2-carboxylic acid 

Downstream Products

• 1403941-84-3 3-chloro-N-o-tolyl-1H-pyrrole-2-carboxamide 
• 1403941-87-6 3-chloro-1-(2-chloroacetamido)-N-o-tolyl-1H-pyrrole-2-carboxamide 
• 1403941-83-2 1-amino-3-chloro-N-o-tolyl-1H-pyrrole-2-carboxamide 
• 1403941-85-4 5-chloro-2-(chloromethyl)-3-o-tolylpyrrolo[1,2-f][1,2,4]triazin-4(3H)-one 
• 1403941-88-7 2-(aminomethyl)-5-chloro-3-o-tolylpyrrolo[1,2-f][1,2,4]triazin-4(3H)-one 
• 1403945-65-2 2-((6-amino-9H-purin-9-yl)methyl)-5-chloro-3-o-tolylpyrrolo[1,2-f][1,2,4]triazin-4(3H)-one 
• 1403945-67-4 2-((6-aminopyrimidin-4-ylamino)methyl)-5-chloro-3-o-tolylpyrrolo[1,2-f][1,2,4]triazin-4(3H)-one 
• 1466566-00-6 (S)-2-(1-aminoethyl)-5-chloro-3-phenylpyrrolo[2,1-f][1,2,4]triazine-4(3H)-one 

Relevant academic research and scientific papers

Synthesis of pyrrolo[2,1-f][1,2,4]triazin-4(3H)-ones: Rearrangement of pyrrolo[1,2-d][1,3,4]oxadiazines and regioselective intramolecular cyclization of 1,2-biscarbamoyl-substituted 1H-pyrroles

Pyrrolo[2,1-f][1,2,4]triazin-4(3H)-ones 12 have been easily prepared via nucleophile-induced rearrangement of pyrrolooxadiazines 11 and regioselective intramolecular cyclization of 1,2-biscarbamoyl-substituted 1H-pyrroles 10. In this work, we demonstrated

Pyrrolotriazinone derivatives as PI3K inhibitors

New pyrrolotriazinone derivatives having the chemical structure of formula (I) are disclosed; as well as process for their preparation, pharmaceutical compositions comprising them and their use in therapy as inhibitors of Phosphoinositide 3-Kinases (PI3Ks)

3,5-Disubstituted-[1,2,4]-oxadiazoles and analogs as activators of caspases and inducers of apoptosis and the use thereof

Disclosed are 3,5-disubstituted-[1,2,4]-oxadiazoles and analogs thereof, represented by the Formula I: wherein Ar1, R2, A, B and D are defined herein. The present invention relates to the discovery that compounds having Formula I are activators of caspases and inducers of apoptosis. Therefore, the activators of caspases and inducers of apoptosis of this invention may be used to induce cell death in a variety of clinical conditions in which uncontrolled growth and spread of abnormal cells occurs.