72178-39-3Relevant articles and documents
Cascade Michael-Aldol reaction: Efficient annulation of sulfonamide chalcones into novel cyclohexenones under solvent-free conditions
Agrawal, Nikita R.,Bahekar, Sandeep P.,Agrawal, Abhijeet R.,Sarode, Prashant B.,Chandak, Hemant S.
, p. 227 - 245 (2016/07/06)
A simple, convenient and efficient synthesis of novel sulfonamide cyclohexenones from differently substituted sulfonamide chalcones has been developed. Syntheses of cyclohexenones have been achieved via cascade Michael-Aldol reaction under solvent free condition. This process features mild and solvent-free synthesis of the titled compounds with high yields (18 examples, up to 95% yield). The synthesized scaffold is a promising intermediate for the further transformation into various heterocyclic compounds.
Inhibitory evaluation of sulfonamide chalcones on β-secretase and acylcholinesterase
Kang, Jae Eun,Cho, Jung Keun,Curtis-Long, Marcus J.,Ryu, Hyung Won,Kim, Jin Hyo,Kim, Hye Jin,Yuk, Heung Joo,Kim, Dae Wook,Park, Ki Hun
, p. 140 - 153 (2013/04/23)
The action of β-secretase (BACE1) is strongly correlated with the onset of Alzheimer's disease (AD). Aminochalcone derivatives were examined for their ability to inhibit BACE1. Parent aminochalcones showed two digit micromolar IC50s against BACE1. Potency
Synthesis and antimicrobial activity of some new cyanopyridines, isoxazoles, pyrazoles, and pyrimidines bearing sulfonamide moiety
Moustafa, Osama S.,Ahmad, Ragaa A.
, p. 475 - 484 (2007/10/03)
Reaction of p-aminoacetophenone 1 with p-substituted benzenesulfonyl chloride 2a,b in pyridine afforded p-acetyl derivatives 3a,b, which was then condensed with araldehydes to yield the corresponding chalcones 4a-f. On condensation of latter chalcones wit
