721942-72-9Relevant academic research and scientific papers
Stability studies of C-4′,6′ acetal benzylmaltosides synthesized as inhibitors of smooth muscle cell proliferation
Mayer, Scott C.,Gallaway, William,Kulishoff, John,Yin, Maisheng,Gadamasetti, Vidya,Mitchell, Robert
, p. 2829 - 2833 (2007/10/03)
In our investigations to synthesize inhibitors of smooth muscle cell (SMC) proliferation, compound 6a displayed submicromolar activity in in vitro antiproliferative assays and reduced intimal thickening using a rat balloon angioplasty model via iv administration. In order to identify analogs that could be administered orally, the chemical instability of the C-4′,6′ acetal of compound 6a was addressed. Several novel variants with increased acid stability and comparable in vitro activity were prepared.
