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55912-20-4

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  • price discount 4-Chloro-3-nitrobenzyl alcohol, 98% RARECHEM AL BD 0170, CAS:55912-20-4 CAS NO.55912-20-4

    Cas No: 55912-20-4

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55912-20-4 Usage

Chemical Properties

LIGHT YELLOW TO LIGHT BROWN POWDER OR NEEDLES

Uses

(4-Chloro-3-nitrophenyl)methanol is used as a reactant in the preparation of benzimidazole sulfonamides as oral S1P1 receptor antagonists.

Check Digit Verification of cas no

The CAS Registry Mumber 55912-20-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,5,9,1 and 2 respectively; the second part has 2 digits, 2 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 55912-20:
(7*5)+(6*5)+(5*9)+(4*1)+(3*2)+(2*2)+(1*0)=124
124 % 10 = 4
So 55912-20-4 is a valid CAS Registry Number.
InChI:InChI=1/C7H6ClNO3/c8-6-2-1-5(4-10)3-7(6)9(11)12/h1-3,10H,4H2

55912-20-4 Well-known Company Product Price

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  • Alfa Aesar

  • (A16024)  4-Chloro-3-nitrobenzyl alcohol, 98%   

  • 55912-20-4

  • 5g

  • 373.0CNY

  • Detail
  • Alfa Aesar

  • (A16024)  4-Chloro-3-nitrobenzyl alcohol, 98%   

  • 55912-20-4

  • 25g

  • 1223.0CNY

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55912-20-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name 4-CHLORO-3-NITROBENZYL ALCOHOL

1.2 Other means of identification

Product number -
Other names 4-chloro-3-nitro-benzyl alcohol

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:55912-20-4 SDS

55912-20-4Relevant articles and documents

Total Synthesis of (-)-Nodulisporic Acids D, C, and B: Evolution of a Unified Synthetic Strategy

Zou, Yike,Li, Xiangqin,Yang, Yun,Berritt, Simon,Melvin, Jason,Gonzales, Stephen,Spafford, Matthew,Smith, Amos B.

, p. 9502 - 9511 (2018)

A unified synthetic strategy leading to the total synthesis of (-)-nodulisporic acids D, C, and B is described. Key synthetic transformations include a nickel-chromium-mediated cyclization, an aromatic ring functionalization employing a novel copper-promoted alkylation, a palladium-catalyzed cross-coupling cascade/indole ring construction, and a palladium-mediated regio- and diastereoselective allylic substitution/cyclization reaction, the latter to construct ring D.

Selective Hydroboration of Carboxylic Acids with a Homogeneous Manganese Catalyst

Barman, Milan K.,Das, Kuhali,Maji, Biplab

, p. 1570 - 1579 (2019/01/30)

Catalytic reduction of carboxylic acid to the corresponding alcohol is a challenging task of great importance for the production of a variety of value-added chemicals. Herein, a manganese-catalyzed chemoselective hydroboration of carboxylic acids has been developed with a high turnover number (>99?000) and turnover frequency (>2000 h-1) at 25 °C. This method displayed tolerance of electronically and sterically differentiated substrates with high chemoselectivity. Importantly, aliphatic long-chain fatty acids, including biomass-derived compounds, can efficiently be reduced. Mechanistic studies revealed that the reaction occurs through the formation of active manganese-hydride species via an insertion and bond metathesis type mechanism.

Discovery of a clinical stage multi-kinase inhibitor sodium (E)-2-{2-methoxy-5-[(2′,4′,6′-trimethoxystyrylsulfonyl)methyl] phenylamino}acetate (ON 01910.Na): Synthesis, structure-activity relationship, and biological activity

Reddy, M. V. Ramana,Venkatapuram, Padmavathi,Mallireddigari, Muralidhar R.,Pallela, Venkat R.,Cosenza, Stephen C.,Robell, Kimberly A.,Akula, Balaiah,Hoffman, Benjamin S.,Reddy, E. Premkumar

experimental part, p. 6254 - 6276 (2011/11/01)

Cyclin D proteins are elevated in many cancer cells, and targeted deletion of cyclin D1 gene in the mammary tissues protects mice from breast cancer. Accordingly, there is an increasing awareness of this novel nonenzymatic target for cancer therapeutics. We have developed novel, nonalkylating styrylbenzylsulfones that induce cell death in wide variety of cancer cells without affecting the proliferation and survival of normal cells. The development of derivatized styrylbenzylsulfones followed logically from a tumor cell cytotoxicity screen performed in our laboratory that did not have an a priori target profile. Modifications of some of the precursor molecules led to lead optimization with regard to tumor cell cytotoxicity. In this report we describe the synthesis and structure-activity relationships of novel, nonalkylating (E)-styrylbenzylsulfones and the development of the novel anticancer agent sodium (E)-2-{2-methoxy-5-[(2′,4′,6′- trimethoxystyrylsulfonyl)methyl]phenylamino}acetate (ON 01910.Na), which is in phase III trials for myelodysplastic syndromes (MDS) associated with aberrant expression of cyclin D proteins.

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