7221-28-5Relevant academic research and scientific papers
Triazolo derivatives of dibenzodiazepines as potential C. N. S. active drug
Joshi, Jyoti U.,Joshi, Bidya S.,Joshi
experimental part, p. 141 - 145 (2010/07/06)
The synthesis of a number of substituted triazolo derivatives of Dibenzodiazepines are reported. The medicinal properties were evaluated through various pharmacological assessments applied on albino mice of either sex taking clozapine as standard drug. A triazolo derivatives having substitution at 8-positions Dibenzodiazepines was found to have for better CNS depressant activity properties as compared to the basic Dibenzodiazepines moeity and among other 8-subsituted derivatives amino substitution exhibited 70 - 80 % antiepileptic properties.
Novel 1,4-benzodiazepines from acylnitroso-derived hetero-Diels-Alder cycloadducts
Surman, Matthew D.,Mulvihill, Mark J.,Miller, Marvin J.
, p. 139 - 141 (2007/10/03)
(matrix presented) N4-Hydroxy-1,4-benzodiazepines were synthesized in a single step from synthetically versatile acylnitroso-derived hetero-Diels-Alder cycloadducts. The efficiency of this transformation was found to be dependent on the NH pKa Of the cycloadduct sulfonamide.
Quinoxaline-phosphonic acid derivatives
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, (2008/06/13)
The disclosure relates to quinoxaline derivatives of Formula I wherein R1, R4, R5, R6, R7 and R8 are as defined in the disclosure, as well as their production and use in medicinal agents.
