72236-26-1

Usage

Uses

Used in Chemical Synthesis:
3,6,9,12,15-PENTAOXAHEPTADECANE-1,17-DIYL BIS-AMINE is used as a building block in chemical synthesis for the creation of various compounds and polymers. Its reactive amino groups facilitate the formation of amide bonds with carboxylic acids and other reactive species, enabling the synthesis of complex molecules.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 3,6,9,12,15-PENTAOXAHEPTADECANE-1,17-DIYL BIS-AMINE is used as a linker or spacer in the development of drug conjugates and prodrugs. Its ability to form stable covalent bonds with various functional groups allows for the attachment of drug molecules to targeting agents or other moieties, improving drug delivery and efficacy.
Used in Bioconjugation:
3,6,9,12,15-PENTAOXAHEPTADECANE-1,17-DIYL BIS-AMINE is used as a bioconjugation agent for the attachment of biologically active molecules, such as peptides, proteins, or nucleic acids, to various surfaces or other macromolecules. Its reactive amino groups enable the formation of stable covalent bonds, allowing for the creation of functional bioconjugates with tailored properties.
Used in Surface Modification:
In the field of materials science, 3,6,9,12,15-PENTAOXAHEPTADECANE-1,17-DIYL BIS-AMINE is used for surface modification of various substrates, such as nanoparticles, polymers, or solid supports. Its reactive amino groups can be used to attach functional groups or other molecules to surfaces, altering their properties, such as hydrophilicity, biocompatibility, or binding affinity.
Used in Analytical Chemistry:
3,6,9,12,15-PENTAOXAHEPTADECANE-1,17-DIYL BIS-AMINE is used as a reagent in analytical chemistry for the detection, separation, or immobilization of various analytes. Its reactive amino groups can be used to form covalent bonds with specific functional groups, enabling the development of novel analytical methods and techniques.

InChI:InChI=1/C12H28N2O5/c13-1-3-15-5-7-17-9-11-19-12-10-18-8-6-16-4-2-14/h1-14H2

Upstream product

• 356046-26-9 1-azido-2-[2-(2-{2-[2-(2-azidoethoxy)ethoxy]ethoxy}ethoxy)ethoxy]ethane 
• 42749-27-9 hexa(ethyleneglycol) ditosylate 
• 52559-90-7 1,17-dichloro-3,6,9,12,15-pentaoxaheptadecane 
• 109789-40-4 3,6,9,12,15-pentaoxaheptadecane-1,17-diyl dimethanesulfonate 
• 2615-15-8 pentaethylene glycol 

Downstream Products

• 143029-08-7 [1-Phenyl-meth-(E)-ylidene]-{2-[2-(2-{2-[2-(2-{[1-phenyl-meth-(E)-ylidene]-amino}-ethoxy)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-ethyl}-amine 
• 189209-27-6 tert-butyl N-[2-[2-[2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy] ethoxy]ethoxy]ethyl]carbamate 
• 1031364-23-4 NSP-2'-(CH₂OMe)-6'-Me-AE-HEG 
• 1031364-06-3 NSP-2'-(CH₂OCH₂CH₂OMe)-6'-Me-AE-HEG-glutarate NHS ester 
• 1031364-29-0 NSP-2'-(CH₂OCH₂CH₂OMe)-6'-Me-AE-HEG-glutarate 
• 1031364-04-1 NSP-2'-(CH₂OCH₂CH₂OMe)-6'-Me-AE-HEG 
• 1357517-06-6 4-[3-(trifluoromethyl)diazirin-3-yl]-N-[2-[2-[2-[2-[2-[2-[4-[3-(trifluoromethyl)diazirin-3-yl]benzoylamino]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethyl]benzamide 
• 1338063-20-9 4-azido-N-[2-[2-[2-[2-[2-[2-[(4-azido-2,3,5,6-tetrafluorobenzoyl)amino]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethyl]-2,3,5,6-tetrafluorobenzamide 
• 143029-12-3 (17R,18R)-17,18-Diphenyl-1,4,7,10,13-pentaoxa-16,19-diaza-cyclohenicosane 
• 143062-17-3 (17S,18R)-17,18-Diphenyl-1,4,7,10,13-pentaoxa-16,19-diaza-cyclohenicosane 

Relevant academic research and scientific papers

Bivalent HIV-1 fusion inhibitors based on peptidomimetics

Membrane fusion is a valid target for inhibition of HIV-1 replication. A 34-mer fragment peptide (C34), which is contained in the HIV-1 envelope protein gp41, has significant anti-HIV activity. Previously, a dimeric derivative of C34 linked by a disulfide bridge at its C-terminus was found to have more potent anti-HIV activity than the C34 peptide monomer. To date, several peptidomimetic small inhibitors have been reported, but most have lower potency than peptide derivatives related to C34. In the present study we applied this dimerization concept to these peptidomimetic small inhibitors and designed several bivalent peptidomimetic HIV-1 fusion inhibitors. The importance of the length of linkers crosslinking two peptidomimetic compounds was demonstrated and several potent bivalent inhibitors containing tethered peptidomimetics were produced.

EXENATIDE MODIFIER AND USE THEREOF

Disclosed are an exenatide modifier for connecting the exenatide to a fatty chain with a carboxy in the terminus thereof by means of a hydrophilic connecting arm, and a use thereof in preparing drugs serving as a GLP-1 receptor agonist; a use in preparing drugs for preventing and/or treating diseases and/or symptoms associated with a low GLP-1 receptor activity; a use in preparing drugs for diseases and/or symptoms associated with glycometabolism; a use in preparing drugs for diabetes; a use in preparing drugs for fatty liver disease, and a use in preparing drugs for losing weight.

Polyacrylamide pseudo crown ethers via hydrogen bond-assisted cyclopolymerization

Polyacrylamide pseudo crown ethers with large in-chain rings (15–24 membered) were synthesized by hydrogen bond-mediated cyclopolymerization of bisacrylamides comprising poly(ethylene oxide) spacers (PEGnDAAm, ethylene oxide units: n = 3–6). The monomers undergo the intramolecular hydrogen bonding of the bisacrylamide units in halogenated solvents to dynamically place the two olefins adjacently. As a result, the bisacrylamides homogeneously allowed controlled radical cyclopolymerization without any macroscopic gelation in 1,2-dichloroethane, even at relatively high concentration of monomers (200 mM), to directly provide precision cyclopolyacrylamides and the related copolymers with high cyclization efficiency (84–98%). Owing to the in-chain ring pendants, a cyclopolyacrylamide had glass transition temperature higher than a corresponding polyacrylamide with linear pendants.

Optimization of the Sensitization Process and Stability of Octadentate Eu(III) 1,2-HOPO Complexes

The synthesis of a series of octadentate ligands containing the 1-hydroxypyridin-2-one (1,2-HOPO) group in complex with europium(III) is reported. Within this series, the central bridge connecting two diethylenetriamine units linked to two 1,2-HOPO chromophores at the extremities (5-LIN-1,2-HOPO) is varied from a short ethylene chain (H(2,2)-1,2-HOPO) to a long pentaethylene oxide chain (H(17O5,2)-1,2-HOPO). The thermodynamic stability of the europium complexes has been studied and reveals these complexes may be effective for biological measurements. Extension of the central bridge results in exclusion of the inner-sphere water molecule observed for [Eu(H(2,2)-1,2-HOPO)]- going from a nonacoordinated to an octacoordinated Eu(III) ion. With the longer chain length ligands, the complexes display increased luminescence properties in aqueous medium with an optimum of 20% luminescence quantum yield for the [Eu(H(17O5,2)-1,2-HOPO)]- complex. The luminescence properties for [Eu(H(14O4,2)-1,2-HOPO)]- and [Eu(H(17O5,2)-1,2-HOPO)]- are better than that of the model bis-tetradentate [Eu(5LINMe-1,2-HOPO)2]- complex, suggesting a different geometry around the metal center despite the geometric freedom allowed by the longer central chain in the H(mOn,2) scaffold. These differences are also evidenced by examining the luminescence spectra at room temperature and at 77 K and by calculating the luminescence kinetic parameters of the europium complexes. (Graph Presented).

Developing bivalent ligands to target CUG triplet repeats, the causative agent of myotonic dystrophy type 1

An expanded CUG repeat transcript (CUGexp) is the causative agent of myotonic dystrophy type 1 (DM1) by sequestering muscleblind-like 1 protein (MBNL1), a regulator of alternative splicing. On the basis of a ligand (1) that was previously reported to be active in an in vitro assay, we present the synthesis of a small library containing 10 dimeric ligands (4-13) that differ in length, composition, and attachment point of the linking chain. The oligoamino linkers gave a greater gain in affinity for CUG RNA and were more effective when compared to oligoether linkers. The most potent in vitro ligand (9) was shown to be aqueous-soluble and both cell- and nucleus-permeable, displaying almost complete dispersion of MBNL1 ribonuclear foci in a DM1 cell model. Direct evidence for the bioactivity of 9 was observed in its ability to disperse ribonuclear foci in individual live DM1 model cells using time-lapse confocal fluorescence microscopy.

Steroidal bivalent ligands for the estrogen receptor: Design, synthesis, characterization and binding affinities

Steroidal bivalent ligands for the estrogen receptor (ER) were designed using crystal structures of ERα dimers as a template. The syntheses of several 17α-ethynylestradiol-based bivalent ligands with varying linker compositions and lengths are described. The binding affinities of these bivalent ligands for ERα and ERβ were determined. In the two series of bivalent ligands that we synthesized, there is a clear correlation between linker length and binding affinity, both of which reach a maximum at the same tether length. Further studies are underway to explore aspects of bivalent ligand and control compound binding to the ERs and their effects on ER dimer formation; these results will be reported in a subsequent publication.

Small-molecule-induced folding of a synthetic polymer

(Chemical Equation Presented) Stack 'em high: A polyimide with pyromellitic diimide units linked by hexaoxy-ethylene segments can be made to fold by cooperative two-point interactions on addition of a folding agent (see scheme). The ammonium group of the folding agent forms complexes with the oxyethylene spacer which greatly facilitates the formation of charge-transfer complexes between the aromatic units of the two components.

Acridinium ester labels having hydrophilic modifiers

The present invention is generally directed to detectable chemiluminescent acridinium ester labels having hydrophilic modifiers; to compositions, complexes and/or conjugates which include such labels; and to processes for performing bioanalytical assays for target analytes which use such labels. Assays for folate, theophylline, and tobramycin (using such labels with hydrophilic modifiers such as nonionic polyethylene glycol and polyionic spermine disulfonate and polyionic spermine dicarboxylate) are described in detail.

Stabilization of nucleic acid amplification cocktails

The present invention provides a cocktail of reagents for nucleic acid amplification that are stabilized by inclusion of a reversible inhibitor of undesirable reactions. Such cocktail of reagents eliminates the requirement for separate preparation and qua

Synthesis and analysis of polyethylene glycol linked P-glycoprotein-specific homodimers based on (-)-stipiamide

A series of five homodimeric polyethylene glycol (PEG) linked homodimers based on the multidrug resistance reversal agent (-)-stipiamide were made and tested for their ability to interact with P-glycoprotein, the protein responsible for multidrug resistance, using ATPase and photoaffinity displacement assays. Key reactions include a new alkoxide-mesylate displacement for the assembly of the PEG linkers and a double Sonogashira coupling reaction.