52559-90-7Relevant academic research and scientific papers
Crown-annelated oligothiophenes as model compounds for molecular actuation
Jousselme, Bruno,Blanchard, Philippe,Levillain, Eric,Delaunay, Jacques,Allain, Magali,Richomme, Pascal,Rondeau, David,Gallego-Planas, Nuria,Roncali, Jean
, p. 1363 - 1370 (2007/10/03)
Crown-annelated quater- (4T) and sexithiophenes (6T) with oligooxyethylene chains of various lengths attached at the 3-positions of the terminal thiophene rings have been synthesized. Analysis of the cation-binding properties of the macrocycles by 1H NMR and UV-vis spectroscopy reveals the formation of a 1:1 complex with Ba2+, Sr2+, or Pb2+ and shows that cation complexation results in a conformational transition in the π-conjugated system. Theoretical analysis of this process by density functional methods predicts that this conformational transition results in a narrowing of the highest occupied-lowest unoccupied molecular orbital gap of the conjugated system with a decrease of the redox potentials (E01 and E02) associated with the formation of the 4T cation radical and dication. Cyclic voltammetry shows that, depending on the binding constant, the presence of metal cation produces a negative or a positive shift of E01 while E02 always shifts negatively. This unusual behavior is discussed in terms of interplay between electrostatic interactions and conformational changes associated with cation binding.
ALKYLATED STYRENES AS PRODRUGS TO COX-2 INHIBITORS
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, (2008/06/13)
The invention encompasses the novel compound of formula (I) useful in the treatment of cyclooxygenase-2 mediated diseases. The invention also encompasses certain pharmaceutical compositions for treatment of cyclooxygenase-2 mediated diseases comprising compounds of formula (I).
Alkylated styrenes as prodrugs to COX-2 inhibitors
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, (2008/06/13)
The invention encompasses the novel compound of Formula I useful in the treatment of cyclooxygenase-2 mediated diseases. STR1 The invention also encompasses certain pharmaceutical compositions for treatment of cyclooxygenase-2 mediated diseases comprising compounds of Formula I.
Application of Two-Dimensional NMR to the Structure Determination of an Unsymmetrical Monosubstituted Bisporphyrin
Costa i Sala, R.,Latour, J.-M.,Bardet, M.
, p. 878 - 880 (2007/10/02)
The complete assignment of (1)H and (13)C data of an unsymmetrical monosubstitute bisporphyrin based on an extensive application of two-dimensional (1)H-(1)H, (1)H-(13)C and (13)C-(13)C shift spectroscopy is described.The (1)H-(1)H shift correlation through dipolar interaction (2D NOESY) was essential to prove the connection of the alkyl fragments and to distinguish protons spatially close but belonging to different units.The additive structural increments method allowed the assignment of the quatenary carbons of tolyl residues.
Ion selective fluorogenic reagents
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, (2008/06/13)
Novel fluorogenic ionophores have been synthesized which selectively bind ions such as potassium and sodium, even in neutral aqueous and alcoholic media and respond to such binding by fluorescence quenching or enhancement. These ionophores are ideal for the selective and direct determination of ions in biological or environmental samples and the like. The ionophores are also suitable for incorporation into fiber optic-based sensors for the continuous in vivo or in vitro monitoring of metal ions in blood or other biological fluids.
Cation-controlled Emission of Crowned Acetophenone
Shirai, Masamitsu,Morimoto, Satoru,Tanaka, Makoto
, p. 1187 - 1190 (2007/10/02)
Effects of alkali- and alkaline-earth-metal cations on the emission properties of 4'-acetylbenzo-15-crown-5 (1a), 4'-acetylbenzo-18-crown-6 (1b), 4'-acetylbenzo-21-crown-7 (1c), and 3,4-dimethoxyacetophenone (2) has been studied in degassed EtOH-MeOH (4:1 v/v) glasses at 77 K.The fluorescence quantum yields (φf) for (1a-c) were negligibly small (0.009-0.014).The phosphorescence quantum yields (φp) for (1a), (1b), (1c), and (2) were 0.26, 0.47, 0.51, and 0.52, respectively, being dependent on the ring size of the crown ether moiety.Binding of alkaline-earth-metal cations decreased the phosphorescence peak at 470 nm concomitant with an appearance of the fluorescence peak at 365 nm.The φf/φp values increased with an increase in the binding ability of alkaline-earth-metal cations to (1a-c).Although φp values of (1a-c) slightly decreased on addition of alkali-metal cations, the exception being a slight enhancement of φp for (1a)-Cs+, (1b)-Cs+, and (1b)-Rb+ systems, no fluorescence peak appeared.
