7225-39-0Relevant academic research and scientific papers
A general and practical synthesis of linear conjugated pentaenoic acids
Souto, Andre A.,Ulises Acuna,Amat-Guerri, Francisco
, p. 5907 - 5910 (1994)
An easy and practical synthesis of all(E)-2,4,6,8,10-dodecapentaenoic acid (1), all(E)-5,7,9,11,13-pentadecapentaenoic acid (2), all(E)-8,10,12,14,16- octadecapentaenoic acid (3) and its (8Z)-isomer (4) by application of the Wittig olefination reaction is described.
The fumagillin biosynthetic gene cluster in Aspergillus fumigatus encodes a cryptic terpene cyclase involved in the formation of β-trans-bergamotene
Lin, Hsiao-Ching,Chooi, Yit-Heng,Dhingra, Sourabh,Xu, Wei,Calvo, Ana M.,Tang, Yi
, p. 4616 - 4619 (2013)
Fumagillin 1 is a meroterpenoid from Aspergillus fumigatus that is known for its anti-angiogenic activity by binding to human methionine aminopeptidase 2. The genetic and molecular basis for biosynthesis of 1 had been an enigma despite the availability of the A. fumigatus genome sequence. Here, we report the identification and verification of the fma gene cluster, followed by characterization of the polyketide synthase and acyltransferase involved in biosynthesis of the dioic acid portion of 1. More significantly, we uncovered the elusive β-trans-bergamotene synthase in A. fumigatus as a membrane-bound terpene cyclase.
Direct conversion of polyconjugated compounds into their corresponding carboxylic acids by Acetobacter aceti
Pini, Elena,Bertacche, Vittorio,Molinari, Francesco,Romano, Diego,Gandolfi, Raffaella
, p. 8638 - 8641 (2008/12/21)
The conversion of polyconjugated aldehydes or alcohols into their corresponding acids was carried out using Acetobacter aceti. The analytical results were compared with those of the acids chemically obtained using a Horner-Wittig reaction.
