7226-27-9

Basic information

• Product Name: 1,6-di-O-benzoylhexitol
• Synonyms: 1,6-Di-O-benzoylhexitol
• CAS NO: 7226-27-9
• Molecular Formula: C₂₀H₂₂O₈
• Molecular Weight: 390.3839
• Mol File: 7226-27-9.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 630.8°C at 760 mmHg
• Flash Point: 223°C
• Density: 1.376g/cm³
• Vapor Pressure: 8.86E-17mmHg at 25°C
• Refractive Index: 1.611
• CAS DataBase Reference: 1,6-di-O-benzoylhexitol(CAS DataBase Reference)
• NIST Chemistry Reference: 1,6-di-O-benzoylhexitol(7226-27-9)
• EPA Substance Registry System: 1,6-di-O-benzoylhexitol(7226-27-9)

Safety Data

• Hazardous Substances Data: 7226-27-9(Hazardous Substances Data)

Usage

Class

Polyol

Explanation

Different sources of media describe the Explanation of 7226-27-9 differently. You can refer to the following data:
1. 1,6-di-O-benzoylhexitol belongs to the class of polyols, which are organic compounds containing multiple hydroxyl groups.
2. It is also known as Dibenzoyl-mannito.
3. The molecular formula of 1,6-di-O-benzoylhexitol is C24H22O6.
4. It is commonly used as a building block in organic synthesis, particularly in the production of other compounds such as pharmaceuticals, agrochemicals, and polymers.
5. Its structure consists of a six-carbon sugar alcohol with benzoyl groups attached to each of the hydroxyl groups.
6. Due to its structure, 1,6-di-O-benzoylhexitol is a versatile and valuable intermediate in chemical processes.
7. It has a high reactivity and ability to undergo various chemical transformations.
8. Its high reactivity makes it an important precursor for the synthesis of complex organic molecules.

Application

Building block in organic synthesis

Structure

Six-carbon sugar alcohol with benzoyl groups

Versatility

Valuable intermediate in chemical processes

Reactivity

High reactivity

Importance

Precursor for complex organic molecules

Upstream product

• 13443-46-4 L-iditol hexaacetate 
• 488-45-9 L-iditol 
• 98-88-4 benzoyl chloride 
• 19895-66-0 1,2:5,6-di-anhydro-D-mannitol 
• 65-85-0 benzoic acid 
• 69-65-8 mannitol 

Downstream Products

• 7464-42-8 O¹,O⁶-dibenzoyl-O²,O⁴;O³,O⁵-((Ξ,Ξ)-dibenzylidene)-D-mannitol 
• 74720-75-5 2,5-anhydro-1,6-di-O-benzoyl-3,4-di-O-tosyl-D-glucitol 
• 82064-06-0 1,4:3,6-dianhydro-2,5-di-O-benzoyl-D-mannitol 
• 51432-64-5 1,6-di-O-benzoyl-3,4-di-O-isopropylidene-D-mannitol 
• 86319-37-1 1,4-anhydro-2,6-di-O-benzoyl-3,5-O-(S)-benzylidene-D-mannitol 
• 7726-97-8 1,4-anhydro-D-mannitol 
• 3013-59-0 O²,O⁴-methanediyl-D-mannitol 
• 5349-04-2 O¹,O⁶-diacetyl-O²,O⁴;O³,O⁵-dimethanediyl-D-mannitol 
• 7465-84-1 4,8-di-(tosyloxymethyl)-1,3,5,7-cis-tetraoxadecalin 
• 111766-72-4 R,R-4,4'-bi-(2,2-dimethyl-5-p-tolylsulphonylmethyldioxolanyl) 
• 111651-33-3 4R,8R,9R,10R-2,2',6,6'-tetramethyl-4,8-bis(p-tolylsulphonyloxymethyl)-1,3,5,7-tetraoxadecalin 
• 863718-22-3 (4S,4aS,8S,8aS)-4,8-Bis-chloromethyl-2,2,6,6-tetramethyl-tetrahydro-[1,3]dioxino[5,4-d][1,3]dioxine 

Relevant articles and documents

Bio-based aromatic polyesters from a novel bicyclic diol derived from d-mannitol

2,4:3,5-Di-O-methylene-d-mannitol, abbreviated as Manx, is a d-mannitol-derived compound with the secondary hydroxyl groups acetalized with formaldehyde. The bicyclic structure of Manx consists of two fused 1,3-dioxane rings, with two primary hydroxyl gro

Bifunctional acyclic nucleoside phosphonates: synthesis of chiral 9-{3-hydroxy[1,4-bis(phosphonomethoxy)]butan-2-yl} derivatives of purines

We report herein a general method for the synthesis of new types of chiral acyclic nucleoside four-carbon bisphosphonates. The alkylation of 2-amino-6-chloropurine and adenine was performed with (2S,3S)- or (2R,3R)-1,4-[bis(diisopropoxyphosphoryl)methoxy]]-3-[(methylsulfonyl)oxy]butan-2-yl benzoate. Alkylations provided (2R,3R) or (2S,3S) N9-substituted nucleobases, which were further converted to other derivatives. These conversions included either a modification of the nucleobase or transformation of the bisphosphonate chain. Subsequent deprotection of the diisopropyl esters with bromotrimethylsilane provided the resulting (2R,3R)- or (2S,3S)-bisphosphonic acids.

Phenylboronic acid as a labile protective agent: the selective derivatisation of 1,2,3-triols

The ability of phenylboronic acid to act as a labile protective agent for open-chain 1,2,3-triols is demonstrated in the highly selective terminal derivatisation of D-mannitol and an antiviral sialic acid derivative. Protection, derivatisation and deprotection are carried out in a single pot, yielding analytically pure products in moderate yield, without the need for chromatography or formal recrystallisation steps. In both classes of compound, the selectivity of protection is found to be complementary to existing methods, providing access to relatively uncommon 1,6-diesters and the 1,6-bis(benzyl ether) of D-mannitol, and 9-o-acylsialic acid derivatives.