7226-27-9

Usage

Class

Polyol

Explanation

1,6-di-O-benzoylhexitol belongs to the class of polyols, which are organic compounds containing multiple hydroxyl groups.

Explanation

It is also known as Dibenzoyl-mannito.

Explanation

The molecular formula of 1,6-di-O-benzoylhexitol is C24H22O6.

Explanation

It is commonly used as a building block in organic synthesis, particularly in the production of other compounds such as pharmaceuticals, agrochemicals, and polymers.

Explanation

Its structure consists of a six-carbon sugar alcohol with benzoyl groups attached to each of the hydroxyl groups.

Explanation

Due to its structure, 1,6-di-O-benzoylhexitol is a versatile and valuable intermediate in chemical processes.

Explanation

It has a high reactivity and ability to undergo various chemical transformations.

Explanation

Its high reactivity makes it an important precursor for the synthesis of complex organic molecules.

Application

Building block in organic synthesis

Structure

Six-carbon sugar alcohol with benzoyl groups

Versatility

Valuable intermediate in chemical processes

Reactivity

High reactivity

Importance

Precursor for complex organic molecules

Upstream product

• 69-65-8 mannitol 
• 98-88-4 benzoyl chloride 
• 19895-66-0 1,2:5,6-di-anhydro-D-mannitol 
• 65-85-0 benzoic acid 
• 488-45-9 L-iditol 
• 13443-46-4 L-iditol hexaacetate 

Downstream Products

• 58881-51-9 O²,O³,O⁴,O⁵-tetraacetyl-O¹,O⁶-dibenzoyl-mannitol 
• 7464-42-8 O¹,O⁶-dibenzoyl-O²,O⁴;O³,O⁵-((Ξ,Ξ)-dibenzylidene)-D-mannitol 
• 51432-64-5 1,6-di-O-benzoyl-3,4-di-O-isopropylidene-D-mannitol 
• 111766-71-3 [(4R,5R)-5-[(4R,5R)-5-(benzoyloxymethyl)-2,2-dimethyl-1,3-dioxolan-4-yl]-2,2-dimethyl-1,3-dioxolan-4-yl]methyl benzoate 
• 111651-31-1 [(4R,4aR,8R,8aR)-4-(benzoyloxymethyl)-2,2,6,6-tetramethyl-4,4a,8,8a-tetrahydro-[1,3]dioxino[5,4-d][1,3]dioxin-8-yl]methyl benzoate 
• 74720-75-5 2,5-anhydro-1,6-di-O-benzoyl-3,4-di-O-tosyl-D-glucitol 
• 82064-06-0 1,4:3,6-dianhydro-2,5-di-O-benzoyl-D-mannitol 
• 22144-41-8 2,5-anhydro-1,6-di-O-benzoyl-D-glucitol 
• 96075-43-3 C₂₆H₃₀O₈ 
• 111651-31-1 C₂₆H₃₀O₈ 
• 3013-59-0 O²,O⁴-methanediyl-D-mannitol 
• 7726-97-8 1,4-anhydro-D-mannitol 
• 86319-37-1 1,4-anhydro-2,6-di-O-benzoyl-3,5-O-(S)-benzylidene-D-mannitol 

Relevant academic research and scientific papers

Bio-based aromatic polyesters from a novel bicyclic diol derived from d-mannitol

2,4:3,5-Di-O-methylene-d-mannitol, abbreviated as Manx, is a d-mannitol-derived compound with the secondary hydroxyl groups acetalized with formaldehyde. The bicyclic structure of Manx consists of two fused 1,3-dioxane rings, with two primary hydroxyl gro

RAPAMYCIN ANALOGS AND USES THEREOF

The present invention provides compounds, compositions thereof, and methods of using the same.

Bifunctional acyclic nucleoside phosphonates: synthesis of chiral 9-{3-hydroxy[1,4-bis(phosphonomethoxy)]butan-2-yl} derivatives of purines

We report herein a general method for the synthesis of new types of chiral acyclic nucleoside four-carbon bisphosphonates. The alkylation of 2-amino-6-chloropurine and adenine was performed with (2S,3S)- or (2R,3R)-1,4-[bis(diisopropoxyphosphoryl)methoxy]]-3-[(methylsulfonyl)oxy]butan-2-yl benzoate. Alkylations provided (2R,3R) or (2S,3S) N9-substituted nucleobases, which were further converted to other derivatives. These conversions included either a modification of the nucleobase or transformation of the bisphosphonate chain. Subsequent deprotection of the diisopropyl esters with bromotrimethylsilane provided the resulting (2R,3R)- or (2S,3S)-bisphosphonic acids.

An iterative acetylene-epoxide coupling strategy for the total synthesis of longimicin C

Longimicin C, a naturally occurring annonaceous acetogenin possessing a C2-symmetrical bis-THF moiety and a short hydrocarbon chain between its THF-containing region and a terminal γ-lactone, was synthesized for the first time. The total synthe

Phenylboronic acid as a labile protective agent: the selective derivatisation of 1,2,3-triols

The ability of phenylboronic acid to act as a labile protective agent for open-chain 1,2,3-triols is demonstrated in the highly selective terminal derivatisation of D-mannitol and an antiviral sialic acid derivative. Protection, derivatisation and deprotection are carried out in a single pot, yielding analytically pure products in moderate yield, without the need for chromatography or formal recrystallisation steps. In both classes of compound, the selectivity of protection is found to be complementary to existing methods, providing access to relatively uncommon 1,6-diesters and the 1,6-bis(benzyl ether) of D-mannitol, and 9-o-acylsialic acid derivatives.

Chiral Ligands for Organometallic Catalysis containing Two Dioxolane Rings

Treatment of D-mannitol 1,6-dibenzoate with a catalytic quantity of toluene-p-sulphonic acid in 2,2-dimethoxypropane leads to the formation of two cyclic acetals, 4R,8R,9R,10R-2,2',6,6'-tetramethyl-4,8-bis(benzoyloxymethyl)-1,3,5,7-tetraoxadecalin and R,R'-4,4'-bi-(2,2-dimethyl-5-benzoyloxymethyldioxolanyl) in comparable amounts.Successive reaction with sodium methoxide in methanol, methanesulphonyl chloride, and lithium or potassium diphenylphosphide gave the corresponding phosphines namely 4S,8S,9S,10S-2,2',6,6'-tetramethyl-4,8-di-1,3,5,7-tetraoxadecalin and S,S-4,4'-bi-.Similarly, starting from L-iditol, the diphosphines 4R,8S,9S,10R-2,2',6,6'-tetramethyl-4,8-di-1,3,5,7-tetraoxadecalin and S,R-4,4'-bi- were obtained.It was demonstrated through (31)P n.m.r. studies that both cis- and trans-chelate complexes of rhodium were formed by these biphosphine ligands.Their potential in asymmetric hydrogenation was demonstrated, for low to moderate yields of amino acids were formed from a variety of enamide precursors.