72293-10-8

Upstream product

• 17449-02-4 p-chlorobenzylidenepropane-1,3-dioic acid 
• 137-07-5 2-amino-benzenethiol 
• 87707-90-2 2-[(2-Amino-phenylsulfanyl)-(4-chloro-phenyl)-methyl]-malonic acid diethyl ester 
• 6827-40-3 diethyl 4-chlorobenzylidenemalonate 

Downstream Products

• 117553-57-8 Methanesulfonic acid (2R,3R)-2-(4-chloro-phenyl)-4-oxo-2,3,4,5-tetrahydro-benzo[b][1,4]thiazepin-3-ylmethyl ester 
• 72293-34-6 (2S,3S)-3-Chloromethyl-2-(4-chloro-phenyl)-2,3-dihydro-5H-benzo[b][1,4]thiazepin-4-one 
• 72293-30-2 (2S,3R)-2-(4-Chloro-phenyl)-3-(4-methyl-piperazin-1-ylmethyl)-2,3-dihydro-5H-benzo[b][1,4]thiazepin-4-one 
• 72293-11-9 (2S,3S)-2-(4-Chloro-phenyl)-3-hydroxymethyl-2,3-dihydro-5H-benzo[b][1,4]thiazepin-4-one 

Relevant academic research and scientific papers

Synthesis of a new potent anti-ulcer and gastric secretory inhibiting agent, (-)-cis-2,3-dihidro-3-(4-methylpiperazinylmethyl)-2-phenyl-1,5-benzothiaze pin-4(5H)-one hydrochloride (BTM-1086), and related compounds

(-)-cis-2,3-Dihydro-3-(4-methylpiperazinylmethyl)-2-phenyl-1,5-benzothiazepin-4(5H)-one hydrochloride (BTM-1086) and its analogues, which possessed potent anti-ulcer and gastric secretory inhibiting activities, were synthesized and the structure of these compounds were established on the basis of spectral and chemical evidences.

1,5-Benzothiazepine compounds

Cis or trans-1,5-benzothiazepine compounds represented by the formula (I): STR1 wherein R1 represents a hydrogen atom, a halogen atom, an alkyl group or an alkoxy group and R2 represents a hydrogen atom, an alkyl group or a hydroxyal