17449-02-4

Upstream product

• 141-82-2 malonic acid 
• 104-88-1 4-chlorobenzaldehyde 
• 75-36-5 acetyl chloride 
• 100-52-7 benzaldehyde 

Downstream Products

• 72293-10-8 2-(4-chloro-phenyl)-4-oxo-2,3,4,5-tetrahydro-benzo[b][1,4]thiazepine-3-carboxylic acid ethyl ester 
• 860375-05-9 (4-chloro-benzyl)-piperidinomethyl-malonic acid 
• 24653-99-4 (2RS,3SR)-2,3-dibromo-3-(4-chlorophenyl)propanoic acid 
• 115370-17-7 (R)-2-[(S)-2-Acetylsulfanylmethyl-3-(4-chloro-phenyl)-propionylamino]-3-benzylsulfanyl-propionic acid ethyl ester 
• 115370-16-6 (R)-2-[(R)-2-Acetylsulfanylmethyl-3-(4-chloro-phenyl)-propionylamino]-3-benzylsulfanyl-propionic acid ethyl ester 
• 115355-27-6 4-chloro-α-<((R,S)-acetylthio)methyl>benzenepropanoic acid 
• 82983-19-5 2-(4-chlorobenzyl)-propenoic acid 
• 21405-64-1 <(4-chlorophenyl)methyl>propanedioic acid 
• 1615-02-7 3-(4-chlorophenyl)prop-2-enoic acid 

Relevant academic research and scientific papers

Synthesis of arylidene propanedioic acids by Knoevenagel condensation for use in ceramic sols

This paper is primarily concerned with the synthesis of arylidene propanedioic acids by Knoevenagel condensation. Generally organic bases pyridine and piperidine are used as catalyst in Knoevenagel condensation which are costly and health hazard. In this research work, Knoevenagel condensation of various aromatic aldehydes (benzaldehyde, salicylaldehyde and p-chlorobenzaldehyde) and active methylenes (malonic acid and ethyl acetoacetate) was carried out in the presence of amino acids (glycine, lysine, hippuric acid, methionine and leucine) as catalyst. Using salicylaldehyde gave coumarin-3-carboxylic acid, a solvent free synthesis. These products were isolated and purified and were characterized through melting points, TLC, IR, mass and 1H NMR. These acids are synthesized for eventual development of organically modified ceramic nano powders.

Synthesis of a new urea derivative: A dual-functional organocatalyst for Knoevenagel condensation in water

A phenylalanine-urea compound-catalyzed Knoevenagel condensation in water is reported. Various aldehydes and active methylene compounds undergo condensation at room temperature to give the desired products in high yields. The mechanism of the condensation of aldehydes with Meldrum's acid catalyzed by the novel urea derivative is also disclosed.

Knoevenagel condensation catalyzed by chemo-selective Ni-nanoparticles in neutral medium

Recyclable Ni-nanoparticles provides an efficient, economic and rapid method for catalyzing Knoevenagel condensation of aldehydes with an active methylene compound at room temperature. The method offers high yield preferably in case of aromatic aldehydes and proceed well in neutral medium. This method provides a wide range of substrate applicability and simple workup procedure. The products need no further purification and the process is environmentally benign.

Knoevenagel condensation catalyzed by USY zeolite

The Knoevenagel condensation of substituted benzaldehydes with active methylene compounds was performed very efficiently by using a USY (ultrastable Y) zeolite as heterogeneous catalyst.

Mercaptoacyl amino acid inhibitors of atriopeptidase. 1. Structure- activity relationship studies of methionine and S-alkylcysteine derivatives

A broad series of N-(3-mercaptoacyl) amino acid derivatives was evaluated for their ability to inhibit atriopeptidase (neutral endopeptidase, EC 3.4.24.11) in vitro and in vivo. Structural parameters studied were (i) the substituent on the 2-position of the 3-mercaptopropionyl moiety, (ii) the amino acid component, (iii) the S-terminal derivative, and (iv) the C- terminal derivative. Optimum activity was observed for derivatives of methionine and S-alkylcysteines. N-[3-Mercapto-2(S)-[(2- methylphenyl)methyl]-1-oxopropyl]-L-methionine was identified as a highly effective inhibitor of atriopeptidase meriting evaluation as a potential cardiovascular therapeutic agent.

ENKEPHALINASE ENZYME INHIBITING COMPOUNDS

Chiral 2-(2-benzyl-3-mercaptopropionylamino)-1-alkanol derivatives and chiral 2-(2-benzyl-3-mercaptopropionylamino)-4-methylthiobutyric acids are inhibitors of enkephalinase enzyme, reflecting their clinical utility as analgesics or anticonvulsant agents, or as therapy for disorders in which endogenous enkephalin levels are below normal.