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723-74-0

1-methyl-2-phenyl-5-trifluoromethyl-1,2-dihydro-3H-pyrazol-3-one is a complex organic compound belonging to the pyrazolone family. It is characterized by a pyrazolone ring system, which consists of a pyrazole (a five-membered ring with two nitrogen atoms) and a ketone group. The molecule features a methyl group at the 1-position, a phenyl group at the 2-position, and a trifluoromethyl group at the 5-position. 1-methyl-2-phenyl-5-trifluoromethyl-1,2-dihydro-3H-pyrazol-3-one is a derivative of the parent compound 1,2-dihydro-3H-pyrazol-3-one, with the addition of these substituents providing unique chemical and physical properties. Due to its specific structure, it may have potential applications in various fields, such as pharmaceuticals, agrochemicals, or materials science, although its specific uses and properties would require further investigation and characterization.

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  • 723-74-0 Structure

  • Basic information

    1. Product Name: 1-methyl-2-phenyl-5-trifluoromethyl-1,2-dihydro-3H-pyrazol-3-one
    2. Synonyms: 1-methyl-2-phenyl-5-trifluoromethyl-1,2-dihydro-3H-pyrazol-3-one
    3. CAS NO:723-74-0
    4. Molecular Formula:
    5. Molecular Weight: 242.2
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 723-74-0.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 1-methyl-2-phenyl-5-trifluoromethyl-1,2-dihydro-3H-pyrazol-3-one(CAS DataBase Reference)
    10. NIST Chemistry Reference: 1-methyl-2-phenyl-5-trifluoromethyl-1,2-dihydro-3H-pyrazol-3-one(723-74-0)
    11. EPA Substance Registry System: 1-methyl-2-phenyl-5-trifluoromethyl-1,2-dihydro-3H-pyrazol-3-one(723-74-0)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 723-74-0(Hazardous Substances Data)

723-74-0 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 723-74-0 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 7,2 and 3 respectively; the second part has 2 digits, 7 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 723-74:
(5*7)+(4*2)+(3*3)+(2*7)+(1*4)=70
70 % 10 = 0
So 723-74-0 is a valid CAS Registry Number.

723-74-0Downstream Products

723-74-0Relevant articles and documents

Synthesis and biological evaluation of polyfluoroalkylated antipyrines and their isomeric O-methylpyrazoles

Agafonova, Natalya,Borisevich, Sophia,Burgart, Yanina,Khursan, Sergey,Krasnykh, Olga,Maslova, Vera,Saloutin, Victor,Shchegolkov, Evgeny,Solodnikov, Sergey,Trefilova, Alexandra,Triandafilova, Galina

, p. 521 - 536 (2019)

Background: Formally belonging to the non-steroidal anti-inflammatory drug class pyrazolones have long been used in medical practices. Objective: Our goal is to synthesize N-methylated 1-aryl-3-polyfluoroalkylpyrazolones as fluorinated analogs of antipyrine, their isomeric O-methylated derivatives resembling celecoxib structure and evaluate biological activities of obtained compounds. Methods: In vitro (permeability) and in vivo (anti-inflammatory and analgesic activities, acute toxicity, hyperalgesia, antipyretic activity, “open field” test) experiments. To suggest the mechanism of biological activity, molecular docking of the synthesized compounds was carried out into the tyrosine site of COX-1/2. Results: We developed the convenient methods for regioselective methylation of 1-aryl-3- polyfluoroalkylpyrazol-5-ols leading to the synthesis N-methylpyrazolones and O-methylpyrazoles as antipyrine and celecoxib analogs respectively. For the first time, the biological properties of new derivatives were investigated in vitro and in vivo. Conclusion: The trifluoromethyl antipyrine represents a valuable starting point in design of the lead series for discovery new antipyretic analgesics with anti-inflammatory properties.

Regiocontrolled N-, O- and C-methylation of 1-phenyl-3-polyfluoroalkyl-1H-pyrazol-5-ols

Nemytova,Shchegol'kov,Burgart, Ya.V.,Slepukhin,Borisevich,Khursan,Saloutin

, p. 72 - 81 (2017/12/26)

The approaches for regiocontrolled N-, O- and C-methylation of 1-phenyl-3-polyfluoroalkyl-1H-pyrazol-5-ols have been developed. The chemoselective N-methylation proved to be an efficient method for the synthesis of polyfluorinated antipyrine analogs. In addition, we reinvestigated the structure of 3-polyfluoroalkyl-1-phenylpyrazol-5-ols by the X-Ray analysis. The quantum-chemical calculations were used for an explanation of methylation processes. The preliminary biological testing revealed a significant analgesic activity of trifluoromethyl-containing antipyrine.

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