72301-66-7

Upstream product

• 532-28-5 (RS)-mandelonitrile 
• 86-57-7 1-Nitronaphthalene 
• 67755-90-2 Ethoxy-1-ethoxy-(phenyl)-acetonitrile 
• 72301-64-5 α-(2,4-Dichlorophenoxy)phenylacetonitrile 
• 89278-08-0 (4-Chloro-phenoxy)-phenyl-acetonitrile 
• 32121-27-0 α-phenoxy-α-phenylacetonitrile 
• 13031-13-5 2-methoxy-2-phenylacetonitrile 

Relevant academic research and scientific papers

Simple Synthesis of Aryl p-Nitroarylacetonitriles by Vicarious Nucleophilic Substitution with Carbanions of Protected Cyanohydrins

Acetals of the cyanohydrins of aromatic aldehydes were deprotonated to generate carbanions, which were used in the vicarious nucleophilic substitution of the hydrogen atom of aromatic and heteroaromatic nitro compounds to form p-nitro-substituted diarylac

Vicarious Nucleophilic Substitution of Hydrogen in Nitroarenes with α-Substituted Nitriles and Esters. Direct α-Cyanoalkylation and α-Carbalkoxyalkylation of Nitroarenes

Carbanions generated from alkanenitriles bearing α-chloro, α-OR, or α-SR groups and from aliphatic esters bearing α-SR groups react with mononitroarenes to replace hydrogen atoms of the nitroaromatic ring ortho or para to the nitro group with α-cyanoalkyl or α-carbalkoxyalkyl substituents.The nucleophilic replacement of hydrogen with such carbanions proceeds faster than substitution of halogen ortho or para to the nitro group.

Vicarious Substitution of Hydrogen in Aromatic Nitro Compounds with Acetonitrile Derivatives

Carbanions of α-phenoxy and thioalkoxy nitriles substitute hydrogen in the para or ortho position of aromatic nitro compounds, giving nitroarylacetonitriles in a process in which phenolate or thiolate anions are vicarious leaving groups.