67755-90-2Relevant academic research and scientific papers
Simple Synthesis of Aryl p-Nitroarylacetonitriles by Vicarious Nucleophilic Substitution with Carbanions of Protected Cyanohydrins
Rad, Nazar,M?kosza, Mieczys?aw
, p. 376 - 380 (2018)
Acetals of the cyanohydrins of aromatic aldehydes were deprotonated to generate carbanions, which were used in the vicarious nucleophilic substitution of the hydrogen atom of aromatic and heteroaromatic nitro compounds to form p-nitro-substituted diarylac
Efficient mercury-free preparation of vinyl and isopropenyl ethers of chiral secondary alcohols and α-hydroxyesters
Dujardin, Gilles,Rossignol, Sandrine,Brown, Eric
, p. 1653 - 1656 (2007/10/02)
Mixed acetals 2a-h and 5a-d, readily deriving from the α-chiral alcohols 1a-h and ethyl vinyl ether or isopropenyl methyl ether, underwent selective elimination of primary alcohol upon treatment with triethylamine and trimethylsilyl trifluoromethanesulfon
Palladium-catalyzed carbonylative cyclization via trapping of acylpalladium derivatives with internal enolates. Its scope and factors affecting the C-to-O ratio
Negishi, El-Ichi,Coperet, Christophe,Sugihara, Takumichi,Shimoyama, Izumi,Zhang, Yantao,Wu, Guangzhong,Tour, James M.
, p. 425 - 436 (2007/10/02)
The Pd-catalyzed carbonylative cyclization reaction involving ω-acyl-substituted acylpalladium derivatives can proceed via intramolecular trapping with either C- or O-enolates; the preferential formation of either 5- or 6-membered rings dictates the C-to-
Applications of Optically Active Aryl Cyanohydrins in the Synthesis of α-Hydroxy Aldehydes, α-Hydroxy Ketones and β-Hydroxy Amines
Jackson, W. Roy,Jacobs, Howard A.,Jayatilake, Gamini S.,Matthews, Barry R.,Watson, Keith G.
, p. 2045 - 2062 (2007/10/02)
Cyanohydrins, prepared in high optical purity from aryl aldehydes, have been converted into α-hydroxy aldehydes, α-hydroxy ketones and β-hydroxy amines without any racemization and frequently with good stereoselectivity for the erythro-diastereoisomer (>90percent) at the newly introduced stereogenic centre.
STEREOCHIMIE DE L'ALKYLATION DE CARBANIONS DERIVES D'α-AMINONITRILES
Hebert, E.,Maigrot, N.,Welvart, Z.
, p. 4683 - 4686 (2007/10/02)
Alkylations with 2-octyl iodide of carbanions generated in THF by LDA from α-aminonitriles or protected cyanohydrines occur with inversion of configuration and an important racemization; these reactions do not involve radical intermediates.
