72344-04-8

Upstream product

• 72344-13-9 3-(4-(methylthio)phenyl)-1-phenylprop-2-en-1-one 
• 100-63-0 phenylhydrazine 
• 98-86-2 acetophenone 
• 3446-89-7 4-(Methylthio)benzaldehyde 

Relevant academic research and scientific papers

Sulfonium salt containing pyrazoline groups and preparation method and application thereof

The invention provides a sulfonium salt containing pyrazoline groups and a preparation method and an application thereof, wherein the general formula of the sulfonium salt is shown in the description;R and R are independently selected from hydroge

Novel 1,3,5-triphenyl-2-pyrazolines as anti-infective agents

Sixteen 1,3,5-triphenyl-2-pyrazolines were synthesized and their anti-infective activities (against Mycobacterium tuberculosis H37Rv, six bacterial and four fungal strains) were tested. Only compound with SO2CH3 in the para position of the A-ring was active against the tubercular strain at 100 μg/ml concentration. All compounds showed good anti infective activity against Escherichia coli and poor activity against Staphylococcus aureus. Compounds 4, 12, 13 and 14 exhibited reasonable activity against all the organisms tested (88% reduction) against four fungi studied at 2 mg/ml. All these compounds possess halogen substitutions. Compound 11 showed very high activity (>90%) against three fungi. Majority of the compounds showed more than 90% inhibition against one or two fungi. Since pyrazolines are reported to inhibit the activity of p-glycoprotein, they may prevent drug resistance developed by microorganism.