72390-25-1Relevant academic research and scientific papers
Hydrazine Hydrate Accelerates Neocuproine–Copper Complex Generation and Utilization in Alkyne Reduction, a Significant Supplement Method for Catalytic Hydrogenation
Chen, Guoliang,He, Xiaoyan,Huang, Gang,Lu, Xiuhong,Wang, Jincheng,Yang, Zhenjiao,Zhang, Yongsheng,Zhang, Zeng
, p. 17696 - 17709 (2021/12/09)
Diimine (HN═NH) is a strong reducing agent, but the efficiency of diimine oxidized from hydrazine hydrate or its derivatives is still not good enough. Herein, we report an in situ neocuproine–copper complex formation method. The redox potential of this complex enable it can serve as an ideal redox catalyst in the synthesis of diimine by oxidation of hydrazine hydrate, and we successfully applied this technique in the reduction of alkynes. This reduction method displays a broad functional group tolerance and substrate adaptability as well as the advantages of safety and high efficiency. Especially, nitro, benzyl, boc, and sulfur containing alkynes can be reduced to the corresponding alkanes directly, which provides a useful complementary method to traditional catalytic hydrogenation. Besides, we applied this method in the preparation of the Alzheimer’s disease drug CT-1812 and studied the mechanism.
Photochemical Transformations. 26. Sensitized and Unsensitized Photoreactions of Some Benzyl Chlorides in tert-Butyl Alcohol
Cristol, Stanley J.,Bindel, Thomas H.
, p. 951 - 957 (2007/10/02)
Benzyl chloride and a variety of meta- and para-substituted derivatives have been irradiated in tert-butylalcohol at 254 nm or in acetone-tert-butyl alcohol mixtures at 300 nm.Quantum and chemical yields of photosolvolysis products (benzyl tert-butyl ether and/or benzyl alcohol), photohomolysis products (bibenzyl and 4-phenyl-2-methyl-2-butanol), and corresponding products from substituted benzylchlorides have been measured as functions of substrate concentration and medium composition.Sensitized reactions favor bond heterolysis, but direct irradiations favor homolysis, although reactions are not clean in either case.There is no correlation between quantum yields for photosolvolysis and Hammett ? or Brown ?+ constants, and no salt effects of added lithium perchlorate were observed, in either direct or sensitized reactions.
