724-18-5

Basic information

• Product Name: 1-Benzhydrylurea
• Synonyms: 1-(Diphenylmethyl)urea;1-Benzhydrylurea
• CAS NO: 724-18-5
• Molecular Formula: C₁₄H₁₄N₂O
• Molecular Weight: 226.27
• Mol File: 724-18-5.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 389.7°C at 760 mmHg
• Flash Point: 189.5°C
• Appearance: /
• Density: 1.156g/cm³
• Vapor Pressure: 2.79E-06mmHg at 25°C
• Refractive Index: 1.604
• CAS DataBase Reference: 1-Benzhydrylurea(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Benzhydrylurea(724-18-5)
• EPA Substance Registry System: 1-Benzhydrylurea(724-18-5)

Safety Data

• Hazardous Substances Data: 724-18-5(Hazardous Substances Data)

Usage

Chemical compound

1-Benzhydrylurea is a chemical compound that is an organic derivative of urea.

Physical state

It is a white crystalline solid.

Uses

It is used in the production of pharmaceuticals and as an intermediate in organic synthesis.

Potential use

1-Benzhydrylurea has been studied for its potential use as an anti-diabetic agent, as it has been found to have hypoglycemic effects in animal studies.

Starting material

It is also used as a starting material in the synthesis of other organic compounds.

InChI:InChI=1/C14H14N2O/c15-14(17)16-13(11-7-3-1-4-8-11)12-9-5-2-6-10-12/h1-10,13H,(H3,15,16,17)

Upstream product

• 57-13-6 urea 
• 91-00-9 Benzhydrylamine 
• 185691-72-9 diphenylmethyl carbamoyl azide 
• 590-28-3 potassium cyanate 
• 5267-34-5 aminodiphenylmethane hydrochloride 
• 525-06-4 diphenyl ketene 
• 142330-27-6 1-benzhydryl-3-(2,2,2-trichloroacetyl)urea 
• 91-01-0 1,1-Diphenylmethanol 
• 14066-73-0 benzophenone semicarbazone 
• 556-89-8 nitrourea 
• 60758-23-8 N-acetyl-N'-benzhydryl-urea 

Downstream Products

• 168779-53-1 1-Benzhydryl-3-(pyridine-4-carbonyl)-urea 
• 168779-52-0 1-Benzhydryl-3-(furan-2-carbonyl)-urea 
• 171258-71-2 1-Benzhydryl-3-(2-phenyl-quinoline-4-carbonyl)-urea 
• 1258791-29-5 C₂₃H₂₂N₂O₂ 
• 60758-34-1 1-Benzhydryl-3-(2-phenoxy-acetyl)-urea 
• 60758-32-9 1-benzhydryl-3-benzoylurea 
• 6744-64-5 N,N'-dibenzhydryl-urea 
• 60758-36-3 1-Benzhydryl-3-(quinoline-2-carbonyl)-urea 
• 60758-23-8 N-acetyl-N'-benzhydryl-urea 

Relevant articles and documents

A Physical Organic Approach to Tuning Reagents for Selective and Stable Methionine Bioconjugation

We report a data-driven, physical organic approach to the development of new methionine-selective bioconjugation reagents with tunable adduct stabilities. Statistical modeling of structural features described by intrinsic physical organic parameters was applied to the development of a predictive model and to gain insight into features driving the stability of adducts formed from the chemoselective coupling of oxaziridine and methionine thioether partners through Redox Activated Chemical Tagging (ReACT). From these analyses, a correlation between sulfimide stabilities and sulfimide ν (C=O) stretching frequencies was revealed. We exploited the rational gains in adduct stability exposed by this analysis to achieve the design and synthesis of a bis-oxaziridine reagent for peptide stapling. Indeed, we observed that a macrocyclic peptide formed by ReACT stapling at methionine exhibited improved uptake into live cells compared to an unstapled congener, highlighting the potential utility of this unique chemical tool for thioether modification. This work provides a template for the broader use of data-driven approaches to bioconjugation chemistry and other chemical biology applications.

Ureas in Organic Synthesis. XI. Reactions of Arylcarbinols with Carbamides in Synthesis of Biologically Active Arylmethylureas

The reaction of arylcarbinols with carbamide in the presence of acids affords the corresponding arylmethylureas.

SYNTHESIS OF ARYLMETHYLUREAS AND THE INFLUENCE OF STRUCTURE ON THEIR ANTISPASMODIC ACTIVITY

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