60758-32-9Relevant academic research and scientific papers
Preparation of a novel polystyrene-based urea resin
Meusel, Manuela,Gütschow, Michael
, p. 2231 - 2233 (2005)
A urea-functionalized polystyrene-resin with a Rink linker was prepared by adaptation of a solution-phase synthesis to solid-phase chemistry. Thereby, a resin-bound acylurea was formed by reacting a Rink-amide resin with trichloroacetyl isocyanate, followed by the thermal removal of the trichloroacetyl group and thus generating the unsubstituted solid-supported urea.
Solid-phase synthesis of disubstituted N -acylureas from resin-bound ureas and acyl chlorides
Haecker, Hans-Georg,Meusel, Manuela,Aschfalk, Melanie,Guetschow, Michael
experimental part, p. 59 - 64 (2011/04/15)
Acylureas (ureides) are valued for their important biological activities. Whereas cyclic acylureas have frequently been the object of solid-phase chemistry, only few reports have focused on the solid-supported preparation of acyclic representatives. We have prepared different types of acylureas on Rink amide resin in three or four steps. The products are either N-acylated (9, 18), N-acylated-N′-alkylated (10, 19), or N-acylated-N-alkylated (22). Characteristic NMR parameters of isomeric acylureas 10, 19, and 22 are discussed.
Evaluation of anticonvulsant and analgesic effects of benzyl- and benzhydryl ureides
Librowski, Tadeusz,Kubacka, Monika,Meusel, Manuela,Scolari, Silvia,Mueller, Christa E.,Guetschow, Michael
, p. 138 - 149 (2008/02/08)
The anticonvulsant effects of benzyl- and benzhydryl ureides in mice models of seizures (maximal electroshock seizure test, pentylenetetrazol test, picrotoxin-induced seizure test) and the influence on spontaneous locomotor activity has been assessed. Fur
