724-91-4

Usage

Also Known As

Diphenylglycolamide

Structure

Contains two phenyl groups attached to the nitrogen and carbon atoms of acetamide.

Main Use

Intermediate for the synthesis of drugs and pharmaceutical products.

Potential Applications

Treatment of cancer
Treatment of central nervous system disorders
Other medical conditions

Additional Uses

Organic synthesis
Building block for various organic compounds

Safety Precautions

Handle with caution
Follow safety guidelines due to potential health hazards.

Upstream product

• 973-42-2 N-Trifluoracetyl-DL-phenylglycin-anilid 
• 4410-33-7 N-phenyl-2-hydroxy-4-phenylacetamide 
• 591-50-4 iodobenzene 
• 700-63-0 Phenylglycinamid 
• 499782-16-0 tert-butyl [1-(phenylcarbamoyl)-1-phenyl-methyl]-carbamate 
• 2835-06-5 phenylglycin 
• 62-53-3 aniline 
• 39801-62-2 N-(trifluoroacetyl)phenylglycine 
• 3108-27-8 4-phenyl-2-(trifluoromethyl)oxazol-5(4H)-one 
• 7647-01-0 hydrogenchloride 
• 33234-02-5 1-nitro-2-(phenylaminocarbonylmethyl)benzene 
• 103-71-9 phenyl isocyanate 
• 100-46-9 benzylamine 

Downstream Products

• 672961-42-1 N-(phenyl)-2-[3-(4-methoxycarbonylphenyl)-thioureido]-2-phenylacetamide 
• 672961-41-0 N-(phenyl)-2-[3-(1-naphthyl)-thioureido]-2-phenylacetamide 
• 672961-40-9 N-(phenyl)-2-[3-(2-nitrophenyl)-thioureido]-2-phenylacetamide 
• 1035968-08-1 (R)-2-amino-N,2-diphenylacetamide 
• 170900-66-0 (S)-2-amino-N,2-diphenylacetamide 
• 1169935-50-5 N-(1-N-phenylcarbamoyl-1-phenylmethyl)-7-chloro-6-fluoro-1,4-dihydro-4-oxo-1-propargyl-1,8-naphthyridine-3-carboxamide 
• 1169935-47-0 N-(1-N-phenylcarbamoyl-1-phenylmethyl)-7-chloro-1,4-dihydro-4-oxo-1-propargyl-1,8-naphthyridine-3-carboxamide 
• 1169935-43-6 N-(1-N-phenylcarbamoyl-1-phenylmethyl)-1,4-dihydro-4-oxo-1-propargyl-1,8-naphthyridine-3-carboxamide 

Relevant academic research and scientific papers

Synthesis of chiral α-amino anilides via a DMEDA-promoted selective C─N coupling reaction of aryl halides and α-aminoamides

A DMEDA-promoted and copper-catalyzed approach has been designed for the coupling of aryl halides and chiral α-aminoamides to afford a range of functionalized chiral α-amino anilides. This method has a higher yield and better reproducibility than those under ligand-free conditions. Of the two amino groups in the same molecule, only the amide NH2 is observed to react, showing high regioselectivity. In addition, no racemization occurs, and the ee can reach 99%. For certain hydroxyl-containing substrates, such as L-tyrosine amide and L-threonine amide, addition of a phase transfer catalyst (15-Crown-5) is necessary for such a transformation.

Synthesis of α-amino acid amides: Ruthenium-catalyzed amination of α-hydroxy amides

Give me an N: The catalytic amination of α-hydroxy amides with a variety of amines, including anilines, primary and secondary aliphatic amines, and ammonia, yields a wide range of α-amino amides (see scheme). This atom-efficient amination protocol proceeds efficiently in the presence of a commercially available [Ru3(CO)12]/DCPE catalyst system. Copyright

1,8-Naphthyridine-3-carboxamide derivatives with anticancer and anti-inflammatory activity

A number of 1-propargyl-1,8-naphthyridine-3-carboxamide derivatives (15-35) have been synthesized and screened for their in vitro cytotoxicity and anti-inflammatory activity. Compounds 22, 31 and 34 have shown high cytotoxicity against a number of cancer cell lines, while compound 24 showed significant anti-inflammatory activity.

ARYLGLYCINE DERIVATIVES FOR USE AS GLYCINE TRANSPORT INHIBITORS

The present invention relates to compounds of Formula (I) and salts solvates and hydrates thereof. The invention further relates to pharmaceutical compositions containing said compounds and methods of treating neurological and neuropsychistric disorders using said compounds.

ARYLGLYCINE DERIVATIVES AND THEIR USE AS GLYCINE TRANSPORT INHIBITORS

The present invention relates to compounds of Formula (I), and salts solvates and hydrates thereof. The invention further relates to pharmaceutical compositions containing said compounds and methods of treating neurological, neuropsychiatric, and gastrointestinal disorders using said compounds.

Carbon Dioxide. A Reagent for the Protection of Nucleophilic Centers and the Simultaneous Activation for Electrophilic Attack. Part 4. The α-Substitution of (i) Benzyl Alcohol and (ii) Benzylamine

Benzyl alcohol is converted into a variety of α-substituted derivatives by a one-pot sequence involving lithiation of an intermediate hemicarbonate ester.Benzylamine is similarly converted by a one-pot sequence to α-substituted benzylamines: here an intermediate carbamate salt is involved.