72406-58-7Relevant academic research and scientific papers
Assembly of substituted 2-alkylquinolines by a sequential palladium-catalyzed Ci-N and Ci-C bond formation
Matsubara, Yoshio,Hirakawa, Saori,Yamaguchi, Yoshihiro,Yoshida, Zen-Ichi
experimental part, p. 7670 - 7673 (2011/10/05)
Diversity: A range of substituted 2-alkylquinolines can be prepared in a general and efficient synthetic approach that employs mild reaction conditions (see scheme). The synthesis is based on a sequential palladium-catalyzed Ci-N and Ci-C bond formation, followed by palladium-catalyzed aromatization, and results in the formation of the desired compounds in one step. Copyright
Facile three-component synthesis of substituted quinolines catalyzed by iridium(III) complex
Nakajima, Takayuki,Inada, Takashi,Igarashi, Takeyuki,Sekioka, Tadashi,Shimizu, Isao
, p. 1941 - 1949 (2007/10/03)
A convenient and efficient synthesis of substituted quinolines via a simple one-pot reaction of an aniline, an aromatic aldehyde, and an enolizable aliphatic aldehyde in the presence of the iridium catalyst [IrCl 2H(cod)]2 under oxygen as an oxidant was developed. The reaction proceeds with Mannich-type imine formation followed by nucleophilic addition to give β-amino aldehydes. Dehydrative cyclization takes place to give dihydroquinoline, which is then dehydrogenated by aerobic oxidation to give 2-aryl-3-alkylquinolines. Dialkylquinolines were obtained by the reaction with anilines and aliphatic aldehydes in good yields.
Arylative amination of aldehydes promoted by aqueous titanium trichloride
Clerici,Porta
, p. 2069 - 2072 (2007/10/02)
Free-radical decomposition of arene-diazonium salts 1, catalyzed by aqueous TiCl3, in the presence of aldehydes 2 and anilines 3 leads to secondary amines 4. A mechanism is proposed, according to which the aryl radical adds to the C-atom of the intermediate protonated imine.
