72417-86-8Relevant academic research and scientific papers
Identification and sar for a selective, nonpeptidyl thrombin inhibitor
Naylor-Olsen, Adel M.,Ponticello, Gerald S.,Lewis, S. Dale,Mulichak, Anne M.,Chen, Zhonguo,Habecker, Charles N.,Phillips, Brian T.,Sanders, William M.,Tucker, Thomas J.,Shafer, Jules A.,Vacca, Joseph P.
, p. 1697 - 1702 (2007/10/03)
A novel, nonpeptidyl thrombin inhibitor, L-636,619 (1), was identified via topological similarity searching over the Merck Corporate Sample Database. X-ray crystallographic studies determined the geometry for ligand binding to the enzyme. Chemical modific
