81745-44-0

Upstream product

• 100-52-7 benzaldehyde 
• 622-32-2 (Z)-benzaldehyde oxime 
• 932-90-1 syn-benzaldehyde oxime 

Downstream Products

• 59591-95-6 3'-phenyl-4'H-spiro[adamantane-2,5'-isoxazole] 
• 923984-15-0 5-(2-ethoxycarbonyl-3-oxobutyl)-3-phenyl-4,5-dihydroisoxazole-5-carboxylic acid ethyl ester 
• 56493-71-1 6-methyl-3-phenyl-5,6-dihydro-4H-[1,2,4]oxadiazine 
• 127491-76-3 2-(benzoylmethylidene)adamantane 
• 147055-13-8 5-phenacylidene-4-azahomoadamantane 
• 326818-12-6 2-Bromo-4-(5-methyl-3-phenyl-isoxazol-4-yl)-pyridine 
• 2065-28-3 methyl 5-methyl-3-phenylisoxazole-4-carboxylate 
• 65788-63-8 5-isothiocyanatomethyl-3-phenyl-4,5-dihydro-isoxazole 
• 72418-40-7 3-phenylisoxazole-5-carbaldehyde 
• 2048-69-3 5-acetyl-3-phenylisoxazole 
• 1081-30-7 3-phenyl-isoxazole-5-carboxylic acid methyl ester 
• 13599-24-1 ethyl 3-phenylisoxazole-5-carboxylate 

Relevant academic research and scientific papers

Depsipeptides Featuring a Neutral P1 Are Potent Inhibitors of Kallikrein-Related Peptidase 6 with On-Target Cellular Activity

Kallikrein-related peptidase 6 (KLK6) is a secreted serine protease that belongs to the family of tissue kallikreins (KLKs). Many KLKs are investigated as potential biomarkers for cancer as well as therapeutic drug targets for a number of pathologies. KLK6, in particular, has been implicated in neurodegenerative diseases and cancer, but target validation has been hampered by a lack of selective inhibitors. This work introduces a class of depsipeptidic KLK6 inhibitors, discovered via high-throughput screening, which were found to function as substrate mimics that transiently acylate the catalytic serine of KLK6. Detailed structure-activity relationship studies, aided by in silico modeling, uncovered strict structural requirements for potency, stability, and acyl-enzyme complex half-life. An optimized scaffold, DKFZ-251, demonstrated good selectivity for KLK6 compared to other KLKs, and on-target activity in a cellular assay. Moreover, DKFZ-633, an inhibitor-derived activity-based probe, could be used to pull down active endogenous KLK6.

Nitrogenous heterocyclic compound with nematocidal activity, preparation method and application thereof

The invention relates to a nitrogenous heterocyclic compound with nematocidal activity, a preparation method and application thereof. Specifically, the invention discloses a compound with a formula (I) or an optical isomer, cis-trans isomer or acceptable salt in agricultural pharmacology and a preparation method thereof. The invention further discloses an agricultural composition containing the compound and application thereof. The compound has excellent nematocidal activity.

Synthesis of functionalized 2-isoxazolines as three-dimensional fragments for fragment-based drug discovery

Abstract The design of new sp3 and spiro-enriched fragments has been achieved from 1,3-dipolar cycloaddition between alkenes and chloro-oximes. The selection of reagents was performed to afford a panel of 2-isoxazoline-containing fragments that show desirable three dimensional (3D) characteristics to allow the probing of biologically-relevant chemical space. Principal moments of inertia (PMI) were calculated to evaluate the 3D diversity. The resulting 3D fragments with suitable physicochemical properties, especially a good solubility, will be used to improve the hit rate of our fragment-based screening.

NOVEL O-ACYLOXIME DERIVATIVES, PREPARATION METHOD THEREOF, AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME FOR PREVENTION AND TREATMENT OF CARDIOVASCULAR DISEASE

The present invention relates to novel O-acyloxime derivatives, a preparation method thereof and a pharmaceutical composition comprising the same for prevention and treatment of cardiovascular disease. The O-acyloxime derivatives according to the present invention may valuably be used for prevention and treatment of cardiovascular diseases such as hyperlipidemia, coronary arterial heart disease, atherosclerosis, and myocardial infarction caused by Lp-PLA2, because they have excellent inhibitory effect of Lp-PLA2.

α-Chloro-o-acylbenzaldoxime derivatives as slime control agents

A composition containing an α-chloro-o-acylbenzaldoxime derivative is effective for inhibiting the formation of slime. The composition has a strong activity for killing microorganisms which form slime, e.g., in the paper and pulp industries without such faults as reducing the whiteness of the paper or pulp, reducing the effect of sizing treatments, degrading the products, etc. A method for controlling slime using this composition is also disclosed.