72450-41-0

Upstream product

• 1563-79-7 [1-13C]-acetic acid 
• 100-51-6 benzyl alcohol 
• 100-39-0 benzyl bromide 
• 23424-28-4 sodium acetate 
• 100-44-7 benzyl chloride 

Downstream Products

• 155060-64-3 benzyl <1-13C>-3-oxo-octanoate 
• 419542-83-9 1-benzyl 4-tert-butyl [1-13C]succinate 
• 72450-42-1 benzyl [1,3-13C₂]acetoacetate 

Relevant academic research and scientific papers

Enzymatic Synthesis of Methylated Terpene Analogues Using the Plasticity of Bacterial Terpene Synthases

Methylated analogues of isopentenyl diphosphate were synthesised and enzymatically incorporated into methylated terpenes. A detailed stereochemical analysis of the obtained products is presented. The methylated terpene precursors were also used in conjunction with various isotopic labellings to gain insights into the mechanisms of their enzymatic formation.

Efficient syntheses of benzyl and n-octyl [1,3-13C 2]acetoacetates, and their application to syntheses of 13C-labelled pyrrole and 13C-labelled hymecromone

Benzyl [1-13C]acetate (2a) was prepared via esterification of sodium [1-13C]acetate (1) with benzyl bromide in the presence of 18-crown-6-ether in 97% yield. n-Octyl [1-13C]acetate (2b) was rapidly obtained by microwave ir

Biosynthesis of the indolizidine alkaloid cyclizidine: incorporation of singly and doubly labelled precursors

Incorporation of CH313C18O2Na and CD3CH213CO2Na into the indolizidine alkaloid cyclizidine 1, produced by Streptomyces species NCIB 11649, shows that the oxygen attached to C-2 is derived intact from acetate and that the cyclopropyl ring is derived from a single intact propionate unit.However, the level and stereochemistry of the incorporation of deuteriated sodium propionate indicates that it undergoes unexpected modification during incorporation into the cyclopropyl ring.

Potential role of fatty acid initiation in the biosynthesis of the fungal aromatic polyketide aflatoxin B1

Earlier work in this laboratory has shown the intact incorporation of [1-13C]hexanoate into averufin (1), a key intermediate in aflatoxin B1 biosynthesis. Parallel experiments with equimolar amounts of [1-13C]butyrate, [1-