72474-41-0

Upstream product

• 1233-23-4 (E)-1-(4-methoxyphenyl)-1,2-diphenylethylene 
• 100-58-3 phenylmagnesium bromide 
• 501-65-5 diphenyl acetylene 
• 119379-68-9 (E)-1,1'-(1-Iodo-1,2-ethenediyl)bisbenzene 
• 93296-09-4 4-methoxyphenylzinc chloride 
• 104-92-7 1-bromo-4-methoxy-benzene 
• 72474-39-6 4-(1,2-diphenylvinyl)anisole 

Downstream Products

• 97800-39-0 cis-1,2-diphenyl-1-<4-(2-diethylaminoethoxy)phenyl>ethylene 

Relevant academic research and scientific papers

Stereoselective Direct Chlorination of Alkenyl MIDA Boronates: Divergent Synthesis of E and Z α-Chloroalkenyl Boronates

The individual molecules of α-chloroalkenyl boronates include both an electrophilic C?Cl bond and a nucleophilic C?B bond, which makes them intriguing organic synthons. Reported herein is a stereodivergent synthesis of both E and Z α-chloroalkenyl N-methyliminodiacetyl (MIDA) boronates through the direct chlorination of alkenyl MIDA boronates using tBuOCl and PhSeCl reagents, respectively. Both reaction processes are stereospecific and the use of sp3-B MIDA boronate is the key contributor to the reactivity. The synthetic value of the boronate products was also demonstrated.

Synthesis of Clomid Using Palladium-Catalysed Cross-Coupling

Two methods of choice for the synthesis of clomid, a tetrasubstituted olefin with antiestrogenic activity, are described.The key reaction is hydroalumination of diphenylacetylene followed by C-C cross-coupling using catalytic amount of Pd0.