72496-79-8Relevant articles and documents
An efficient: T -BuOK promoted C3-chalcogenylation of indoles with dichalcogenides
Yu, Yuanzu,Zhou, Yan,Song, Zengqiang,Liang, Guang
supporting information, p. 4958 - 4962 (2018/07/25)
A versatile and efficient method for the synthesis of 3-chalcogenyl-indoles from indoles and dichalcogenides employing t-BuOK as a promoter at room temperature has been achieved. The present protocol exhibited a broad functional group tolerance. Diverse 3-sulfenyl- and 3-selenyl-indoles were rapidly obtained in good to excellent yields with high regioselectivities. It is noteworthy that this transformation was applicable to N-protected and N-unprotected indoles, allowing N-deprotection and C3-chalcogenylation of indoles in one step.
Catalytic Synthesis of 3-Thioindoles Using Bunte Salts as Sulfur Sources under Metal-Free Conditions
Qi, Hong,Zhang, Tongxin,Wan, Kefeng,Luo, Meiming
, p. 4262 - 4268 (2016/06/09)
An efficient catalytic method for the synthesis of 3-thioindoles has been successfully developed, which uses odorless, stable, readily available crystalline Bunte salts as the sulfenylating agents, iodine as nonmetallic catalyst, and DMSO as both the oxid
Preparation method of 3-indole thioether
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Paragraph 0015, (2016/10/08)
According to the invention, Bunte salt is employed as a sulfur source to prepare 3-indole thioether. At a certain temperature, elementary iodine or hydroiodic acid and salts thereof is employed as a catalyst, dimethyl sulfoxide is employed as an oxidant,
Catalyst-free thiolation of indoles with sulfonyl hydrazides for the synthesis of 3-sulfenylindoles in water
Yang, Yu,Zhang, Sheng,Tang, Lin,Hu, Yanbin,Zha, Zhenggen,Wang, Zhiyong
supporting information, p. 2609 - 2613 (2016/05/24)
A catalyst-free thiolation of indoles with sulfonyl hydrazides was efficiently developed in water under mild conditions without any ligand or additive. The reaction provided a variety of 3-sulfenylindoles with good to excellent yields and the only by-products were nitrogen and water.
Metal- and base-free syntheses of aryl/alkylthioindoles by the iodine-induced reductive coupling of aryl/alkyl sulfonyl chlorides with indoles
Kumaraswamy, Gullapalli,Raju, Ragam,Narayanarao, Vykunthapu
, p. 22718 - 22723 (2015/06/02)
An Iodine-catalysed process for an efficient and scalable sulfenylation protocol for indoles employing aryl-/alkyl sulfonyl chlorides has been developed. A series of sterically and electronically divergent aryl-/alkyl sulfonyl chlorides participated in th
Byproduct promoted regioselective sulfenylation of indoles with sulfinic acids
Liu, Cong-Rong,Ding, Liang-Hui
supporting information, p. 2251 - 2254 (2015/03/04)
An unprecedented method to synthesise 3-sulfenylindoles is demonstrated via byproduct promoted sulfenylation of indoles with sulfinic acids in the absence of an external catalyst. The reaction selectively afforded structurally diverse indole thioethers in good to excellent yields in 1,2-dichloroethane at 80 °C. This journal is
K2S2O8/arenesulfinate: An unprecedented thiolating system enabling selective sulfenylation of indoles under metal-free conditions
Rao, Honghua,Wang, Ping,Wang, Jianchun,Li, Zhongfeng,Sun, Xinzhan,Cao, Shengli
, p. 49165 - 49169 (2014/12/10)
An unprecedented thiolating system K2S2O8/arenesulfinate is described for selective sulfenylation of indoles in CH3CN/H2O. This metal-free strategy enables a simple, efficient and environment-benign approach to the pharmaceutically important candidates, 3-arylthioindoles. Catalytically reactive halogen and aryl groups are well tolerated. This journal is
Iodine-catalyzed regioselective sulfenylation of indoles with sulfonyl hydrazides
Yang, Fu-Lai,Tian, Shi-Kai
supporting information, p. 4929 - 4932 (2013/06/04)
New S in town: Sulfonyl hydrazides smoothly undergo sulfenylation with indoles in the presence of 10 mol % I2 to give structurally diverse indole thioethers in moderate to excellent yields with extremely high regioselectivity. This study paves the way for the use of sulfonyl hydrazides as unique sulfur electrophiles in chemical synthesis. Copyright
A New Synthesis of 3-Arylthioindoles
Atkinson, Joseph G.,Hamel, Pierre,Girard, Yves
, p. 480 - 481 (2007/10/02)
The reaction of the anions of indoles with diaryl disulfides in dimethylformamide at room temperature gives the 3-arylthioindoles in 59-91percent yield.
