7250-84-2

Basic information

• Product Name: 4-(chloromethyl)-2-thiazolamine
• Synonyms: 4-(chloromethyl)-1,3-thiazol-2-amine;4-(Chloromethyl)thiazol-2-amine;4-(Chloromethyl)-2-thiazolamine;2-Amino-4-(chloromethyl)thiazole
• CAS NO: 7250-84-2
• Molecular Formula: C₄H₅ClN₂S
• Molecular Weight: 148.61
• Mol File: 7250-84-2.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 299.7°Cat760mmHg
• Flash Point: 135°C
• Appearance: /
• Density: 1.455g/cm³
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 4-(chloromethyl)-2-thiazolamine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(chloromethyl)-2-thiazolamine(7250-84-2)
• EPA Substance Registry System: 4-(chloromethyl)-2-thiazolamine(7250-84-2)

Safety Data

• Hazardous Substances Data: 7250-84-2(Hazardous Substances Data)

Usage

General Description

4-(chloromethyl)-2-thiazolamine is a chemical compound with the molecular formula C5H6ClNS. It is a thiazolamine derivative that contains a chloromethyl group attached to the 4-position of the thiazole ring. 4-(chloromethyl)-2-thiazolamine has potential applications in organic synthesis and medicinal chemistry, as it can be used as a building block for the synthesis of various bioactive compounds. It may also exhibit biological activity itself, although specific studies on its pharmacological properties are limited. Due to its chloromethyl group, this compound should be handled with caution and in accordance with proper safety protocols due to its potential reactivity and toxicity.

Upstream product

• 17356-08-0 thiourea 
• 78-95-5 chloroacetone 
• 534-07-6 1,3-Dichloroacetone 

Downstream Products

• 7460-59-5 N-(4-(chloromethyl)thiazol-2-yl)acetamide 
• 1187837-01-9 4-{[({[3-(methylsulfanyl)phenyl](1-methyl-1H-tetrazol-5-yl)methylene}amino)oxy]methyl}-1,3-thiazol-2-amine 
• 1596340-74-7 N-(4-chloromethylthiazol-2-yl)-3-(4-methanesulfonylphenoxy)-5-(3-methylpyridine-2-yl)benzamide 
• 144163-74-6 4-methylaminomethyl-1,3-thiazol-2-amine 
• 863454-76-6 N-{4-chloromethyl-1,3-thiazol-2-yl}-3-(1-methylethyl)oxy-5-[4-(methylsulfonyl)phenoxy]benzamide 

Relevant articles and documents

Carbon tetrabromide mediated oxidative cyclocondensation of ketones and thioureas: An easy access to 2-aminothiazoles

A simple, mild, and efficient one-pot method for the synthesis of substituted 2-aminothiazoles has been reported. The reaction involves the formation of sulfenyl bromide as an umpolung intermediate of nucleophilic sulfur, which is responsible for C-S bond formation leading to oxidative cyclization of ketones and thioureas to furnish the desired products. Carbon tetrabromide was used as a convenient and mild brominating reagent under basic condition at room temperature to give 2-aminothiazoles in good to excellent yields.

HETROARYL BENZAMIDE DERIVATIVES FOR USE AS GLK ACTIVATORS IN THE TREATMENT OF DIABETES

Compounds of Formula (I) wherein: R1 is hydroxymethyl; R2 is selected from -C(O)NR4R5, SO2NR4R5, S(O)pR4 and HET-2; HET-1 is a 5- or 6-membered, optionally substituted C-linked heteroaryl ring; HET-2 is a 4-, 5- or 6-membered, C- or N-linked optionally substituted heterocyclyl ring; R3 is selected from halo, fluoromethyl, difluoromethyl, trifluoromethyl, methyl, methoxy and cyano; R4 is selected from for example hydrogen, optionally substituted (1-4C)alkyl and HET-2; R5 is hydrogen or (1-4C)alkyl; or R4 and R5 together with the nitrogen atom to which they are attached may form a heterocyclyl ring system as defined by HET-3; HET-3 is for example an optionally substituted N-linked, 4, 5 or 6 membered, saturated or partially unsaturated heterocyclyl ring; p is (independently at each occurrence) 0, 1 or 2; m is 0 or 1; n is 0, 1 or 2; provided that when m is 0, then n is 1 or 2; or a salt, pro drug or solvate thereof, are described. Their use as GLK activators, pharmaceutical compositions containing them, and processes for their preparation are also described.

PHARMACOLOGICALLY ACTIVE GUANIDINE COMPOUNDS

The compounds are substituted thioalkyl-, aminoalkyl-and oxyalkyl-guanidines which are inhibitors of histamine activity.