7460-59-5

Usage

InChI:InChI=1/C6H7ClN2OS/c1-4(10)8-6-9-5(2-7)3-11-6/h3H,2H2,1H3,(H,8,9,10)

Upstream product

• 7250-84-2 2-Amino-4-chloromethyl-1,3-thiazole 
• 108-24-7 acetic anhydride 
• 59608-97-8 4-(chloromethyl)thiazol-2-amine hydrochloride 
• 591-08-2 N-acetylthiourea 
• 534-07-6 1,3-Dichloroacetone 
• 591-08-2 acetylthiourea 
• 75-36-5 acetyl chloride 

Downstream Products

• 16444-13-6 N-(4-formyl-1,3-thiazol-2-yl)acetamide 
• 16443-97-3 2-acetylamino-5-bromo-thiazole-4-carbaldehyde 
• 16443-89-3 4-(2-acetylamino-thiazol-4-ylmethylene)-2-phenyl-4H-oxazol-5-one 
• 16443-95-1 4-(2-acetylamino-5-chloro-thiazol-4-ylmethylene)-2-phenyl-4H-oxazol-5-one 
• 16444-01-2 4-(2-acetylamino-5-bromo-thiazol-4-ylmethylene)-2-phenyl-oxazol-5-one 
• 92368-43-9 N-[5-nitro-4-(phenylimino-methyl)-thiazol-2-yl]-acetamide 
• 93087-04-8 N-[5-nitro-4-(p-tolylimino-methyl)-thiazol-2-yl]-acetamide 
• 96875-36-4 N-(2-acetylamino-5-nitro-thiazol-4-ylmethylene)-N',N'-dimethyl-N-oxy-benzene-1,4-diamine 
• 874899-73-7 {[2-(acetylamino)-1,3-thiazol-4-yl]methyl}(triphenyl)phosphonium chloride 
• 897935-05-6 N-(4-((4-phenylpiperazin-1-yl)methyl)thiazol-2-yl)acetamide trifluoroacetate 
• 620103-14-2 N-(4-phenoxymethyl-thiazol-2-yl)-acetamide 
• 133691-41-5 N-{4-[(4-nitro-phenylsulfanyl)-methyl]-thiazol-2-yl}-acetamide 
• 79386-95-1 2-acetamido-4-(4-benzhydrylpiperazin-1-ylmethyl)thiazole 
• 408367-61-3 N-[4-({[2-(acetylamino)-1,3-thiazol-4-yl]methyl}amino)phenyl]-4'-(trifluoromethyl)-1,1'-biphenyl-2-carboxamide 

Relevant academic research and scientific papers

N -substituted -2 - amino -4 - saccharin-substituted methylthiazole compound with bactericidal activity Preparation method and application

N -substituted -2 - amino -4 - saccharin-substituted methylthiazole compounds with bactericidal activity, a preparation method and an application thereof relate to the technical field of organic synthesis and agricultural chemicals. Experiments prove that

SUBSTITUTED PYRIDINES AS INHIBITORS OF DNMT1

The invention is directed to substituted pyridine derivatives. Specifically, the invention is directed to compounds according to Formula (Iar): (Iar) wherein Yar, X1ar, X2ar, R1ar, R2ar, R3ar, R4ar and R5ar are as defined herein; or a pharmaceutically acceptable salt or prodrug thereof. The compounds of the invention are selective inhibitors of DNMT1 and can be useful in the treatment of cancer, pre-cancerous syndromes, beta hemoglobinopathy disorders, sickle cell disease, sickle cell anemia, and beta thalassemia, and diseases associated with DNMT1 inhibition. Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting DNMT1 activity and treatment of disorders associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.

Thiazole compounds and methods of use

The invention relates to thiazole compounds of Formula I and Formula II and compositions thereof useful for treating diseases mediated by protein kinase B (PKB) where the variables have the definitions provided herein. The invention also relates to the therapeutic use of such thiazole compounds and compositions thereof in treating disease states associated with abnormal cell growth, cancer, inflammation, and metabolic disorders.

Amide derivatives

The present invention relates to the compounds of formula I their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above-mentioned compounds, pharmaceutical compositions containing them and thei

Modulators of the glucocorticoid receptor, AP-1, and/or NF-kB activity and use thereof

A class of novel non-steroidal compounds are provided which are useful in treating diseases associated with modulation of the glucocorticoid receptor, AP-1, and/or NF-κB activity including obesity, diabetes, inflammatory and immune diseases, and have the

Substituted heteroaryl amide modulators of glucocorticoid receptor, AP-1, and/or NF-kB activity and use thereof

The present invention relates to new class of non-steroidal compounds which are useful in treating diseases associated with modulation of the glucocorticoid receptor, AP-1, and/or NF-κB activity including obesity, diabetes, inflammatory- and immune-associ

Synthesis of 2,4-Disubstituted Thiazoles and Selenazoles as Potential Antifilarial and Antitumor Agents. 2. 2-Arylamido and 2-Alkylamido Derivatives of 2-Amino-4-(isothiocyanatomethyl)thiazole and 2-Amino-4-(isothiocyanatomethyl)selenazole

The synthesis of a series of 2-arylamido and 2-alkylamido derivatives of 2-amino-4-(isothiocyanatomethyl)thiazole and 2-amino-4-(isothiocyanatomethyl)selenazole is described.In vitro antiproliferative evaluations were carried out using L1210 cells.The 2-(