7252-50-8

Usage

Uses

Used in Pharmaceutical Industry:
Hydroxy(6-methyl-2-pyridyl)methyl 6-methyl-2-pyridyl ketone is used as a building block in the synthesis of pharmaceuticals and organic compounds. Its unique structure allows it to be a key component in the development of new drugs, contributing to the advancement of medicinal chemistry.
Used in Organic Chemical Reactions:
hydroxy(6-methyl-2-pyridyl)methyl 6-methyl-2-pyridyl ketone serves as a reagent in various organic chemical reactions, facilitating the synthesis of complex organic molecules. Its presence of a hydroxyl group and a ketone moiety makes it a versatile intermediate for use in a wide range of chemical processes.
It is important to handle hydroxy(6-methyl-2-pyridyl)methyl 6-methyl-2-pyridyl ketone with care and follow proper safety protocols due to its potential hazards.

InChI:InChI=1/C14H14N2O2/c1-9-5-3-7-11(15-9)13(17)14(18)12-8-4-6-10(2)16-12/h3-8,13,17H,1-2H3

Upstream product

• 108-48-5 2,6-dimethylpyridine 
• 6630-11-1 1,2-bis(6-methylpyridin-2-yl)ethane-1,2-dione 
• 1121-60-4 pyridine-2-carbaldehyde 
• 1122-71-0 2-(Hydroxymethyl)-6-methylpyridine 

Downstream Products

• 6630-11-1 1,2-bis(6-methylpyridin-2-yl)ethane-1,2-dione 
• 6630-20-2 1,2-bis-(6-methyl-pyridin-2-yl)-ethane-1,2-diol 

Relevant academic research and scientific papers

Synthesis, characterisation and crystal structure of a co-crystal of two components: 1,2-bis(6-methylpyridin-2-yl)ethane-1,2-dione and 1-(pyridin-2-yl)-2-(6-methylpyridin-2-yl)ethane-1,2-dione

A condensation reaction of an equimolar ratio of 2-pyridinecarboxaldehyde and (6-methylpyridin-2-yl)methanol without a catalyst in a solvent-free reaction at 140°C was expected to yield 2-hydroxy-[1,2-bis(6-methylpyridin-2-yl)] ethan-1-one. FT-IR spectroscopy of the yellow-brown solid reaction product indicated the presence of a -CO-COH- group. The solid compound was treated with cyclohexane and green crystals were produced. The crystals were characterised by FT-IR, 1H NMR, El mass spectrometry and single-crystal X-ray diffraction. The molecular and crystal structure determined by single-crystal X-ray diffraction resolved one crystal showing two molecular components [C 13H10N2O2 and C14H 12N2O2] at a ratio of 60.4:39.6 [C 13.40H10.79N2O2]. Both compounds co-crystallise in the triclinic space group P-1, with a = 7.859(5), b = 8.021(14), c = 9.060(5) A, α = 101.36(2)°, β= 90.06(3)°, γ = 90.92(3)°, V = 559.8(5) A3, Z= 2. The compounds were 1,2-bis(6-methylpyridin-2-yl)ethane-1,2-dione and 1-(pyridin-2-yl)-2-(6-methylpyridin-2-yl)ethane-1,2-dione. These results are important because they confirm that condensation in a solvent- and catalyst-free reaction yielded precursors that were converted into α-diketone compounds by the action of solvent and oxygen.