725211-47-2Relevant academic research and scientific papers
A novel one-pot four-component access to tetrahydro-β-carbolines by a coupling-amination-aza-annulation-Pictet-Spengler sequence (CAAPS)
Karpov, Alexei S.,Oeser, Thomas,Mueller, Thomas J. J.
, p. 1502 - 1503 (2004)
The four-component coupling-amination-aza-annulation-Pictet-Spengler (CAAPS) sequence of acid chlorides 1, terminal alkynes 2, tryptamine derivatives 6, and acryloyl chloride derivatives 4 represents a facile and rapid one-pot access to tetrahydro-β-carbolines 7 in moderate to good yields.
A diversity oriented four-component approach to tetrahydro-β- carbolines initiated by Sonogashira coupling
Karpov, Alexei S.,Rominger, Frank,Mueller, Thomas J. J.
, p. 4382 - 4391 (2007/10/03)
A consecutive four-component synthesis of highly-substituted tetrahydro-β-carbolines 6 can be achieved by a coupling-aminatio-aza- annulation-Pictet-Spengler (CAAPS) sequence creating five new a-bonds and four new Stereocenters in a one-pot fashion. The s
