72559-76-3

Basic information

• Product Name: 9α-fluoro-6β,11β,17α,21-tetrahydroxy-16β-methyl-1,4-pregnadiene-3,20-dione 21-acetate
• CAS NO: 72559-76-3
• Molecular Weight: 450.504
• Mol File: 72559-76-3.mol

Chemical Properties

• CAS DataBase Reference: 9α-fluoro-6β,11β,17α,21-tetrahydroxy-16β-methyl-1,4-pregnadiene-3,20-dione 21-acetate(CAS DataBase Reference)
• NIST Chemistry Reference: 9α-fluoro-6β,11β,17α,21-tetrahydroxy-16β-methyl-1,4-pregnadiene-3,20-dione 21-acetate(72559-76-3)
• EPA Substance Registry System: 9α-fluoro-6β,11β,17α,21-tetrahydroxy-16β-methyl-1,4-pregnadiene-3,20-dione 21-acetate(72559-76-3)

Safety Data

• Hazardous Substances Data: 72559-76-3(Hazardous Substances Data)

Upstream product

• 59860-91-2 9α-fluoro-3,11β,17α,21-tetrahydroxy-16β-methyl-1,3,5-pregnatriene-20-one 21-acetate 3-benzoate 
• 987-24-6 betamethasone 21-acetate 

Downstream Products

• 72560-07-7 9α-fluoro-11β,17α,21-trihydroxy-16β-methyl-1,4-pregnadiene-3,6,20-trione 17-benzoate 
• 82926-63-4 9α-fluoro-11β,17α,21-trihydroxy-16β-methyl-1,4-pregnadiene-3,6,20-trione 17-butyrate 

Relevant articles and documents

Selenium dioxide oxidation of steroidal 1,4-dien-3-ones. A simple and convenient route to 6-hydroxycorticosteroids

A convenient one-step procedure for the chemical synthesis of 6-hydroxycorticosteroids involving allylic oxidation of selenium dioxide is described.

Synthesis and topical antiinflammatory potencies of a series of 6-keto- and Δ6-6-acyloxybetamethasone derivatives

6-Keto and Δ6-6-acyloxybetamethasone esters were synthesized, and tested for topical antiinflammatory potency using a modification of the Tonelli croton ear assay. The introduction of a 6-keto group generally led to retention of topical antiinflammatory potencies when compared to the corresponding 6-desoxycorticoids. In contrast, introduction of the Δ6-6-acyloxy moiety into betamethasone 17,21-dipropionate reduced antiinflammatory potency.