72560-07-7Relevant academic research and scientific papers
Synthesis and topical antiinflammatory potencies of a series of 6-keto- and Δ6-6-acyloxybetamethasone derivatives
Draper,Berkenkopf,Carlon,Fernandez,Monahan,Lutsky
, p. 317 - 322 (2007/10/02)
6-Keto and Δ6-6-acyloxybetamethasone esters were synthesized, and tested for topical antiinflammatory potency using a modification of the Tonelli croton ear assay. The introduction of a 6-keto group generally led to retention of topical antiinflammatory potencies when compared to the corresponding 6-desoxycorticoids. In contrast, introduction of the Δ6-6-acyloxy moiety into betamethasone 17,21-dipropionate reduced antiinflammatory potency.
