72572-18-0

Basic information

• Product Name: 1H-Benzimidazole,5-ethyl-(9CI)
• Synonyms: 1H-Benzimidazole,5-ethyl-(9CI);6-Ethyl-1H-benzo[d]iMidazole
• CAS NO: 72572-18-0
• Molecular Formula: C9H10N2
• Molecular Weight: 146.1891
• Product Categories: BENZIMIDAZOLE
• Mol File: 72572-18-0.mol

Chemical Properties

• Boiling Point: 361.9±11.0 °C(Predicted)
• Appearance: /
• Density: 1.142±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 12.87±0.10(Predicted)
• CAS DataBase Reference: 1H-Benzimidazole,5-ethyl-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Benzimidazole,5-ethyl-(9CI)(72572-18-0)
• EPA Substance Registry System: 1H-Benzimidazole,5-ethyl-(9CI)(72572-18-0)

Safety Data

• Hazardous Substances Data: 72572-18-0(Hazardous Substances Data)

Usage

Chemical Family

1H-Benzimidazole, 5-ethyl-(9CI) belongs to the benzimidazole family, which is a group of heterocyclic compounds.

Bicyclic Structure

The benzimidazole family is characterized by a bicyclic structure, which means that the compounds have two rings of atoms in their structure.

Ethyl Group

The presence of an ethyl group at the 5-position of the benzimidazole ring gives the compound its specific properties and potential applications.

Biological Activities

Benzimidazoles have been linked to various biological activities, including antimicrobial, antiviral, and anticancer effects.

Pharmaceutical Research

As a result of their potential biological activities, 1H-Benzimidazole, 5-ethyl-(9CI) could be of interest in pharmaceutical research and drug development.

Potential Applications

The chemical structure and properties of 1H-Benzimidazole, 5-ethyl-(9CI) make it a potentially valuable compound for further study and potential applications in the future.

Upstream product

• 67-56-1 methanol 
• 3663-35-2 4-ethyl-2-nitroaniline 

Relevant articles and documents

Microwave use of amidine compounds in the aqueous phase benzoate synthesis of benzimidazole compounds method

The invention discloses a microwave the use of amidine compounds in the aqueous phase benzoate synthesis of benzimidazole compounds, in the aqueous phase under microwave conditions adding benzoic amidine compound under alkaline condition [...] into benzimidazole reaction, invention an environment-friendly, the operation is simple, cheap and safe, efficient process for preparing benzimidazole method. Compared with the prior art, this method not only can be applied to a large number of functional groups, the productive rate is high, few by-products, and the operation is simple, safe, low cost, environmental protection; .

A continuous compound benzene and imidazole compounds

The invention discloses a method for continuously synthesizing a benzimidazole compound. The method comprises the steps:in a fixed bed reactor, firstly reducing and activating a loaded multi-metal solid catalyst by hydrogen; then using inert gas as carrier gas; adjusting the temperature to 130-250 DEG C and the pressure at 2-10 MPa; continuously introducing mixed raw materials of an ortho-nitroaniline compound shown in a formula (I), fatty alcohol shown in a formula (II) and distilled water iknto the fixed bed reactor by using a high pressure pump; feeding the reactants which are cooled by a condenser to a gas-liquid separator to collect a liquid product so as to obtain the benzimidazole compound shown in a formula (III), wherein the loaded multi-metal solid catalyst is a Cu-Pd-M/Al2O3 catalyst. According to the method disclosed by the invention, multiple intermittent reactions are changed to a one-step continuous reaction, so that the production process is simplified, generation of byproducts is reduced, the conversion rate can reach 100% to the maximum extent, and the yield of the target product benzimidazole compound can reach 99% to the maximum extent. The formulae are shown in the description.