726192-09-2

Basic information

• Product Name: Methanesulfonic acid (R)-1-(4-methanesulfonyl-phenyl)-ethyl ester
• Synonyms: Methanesulfonic acid (R)-1-(4-methanesulfonyl-phenyl)-ethyl ester
• CAS NO: 726192-09-2
• Molecular Weight: 278.35
• Mol File: 726192-09-2.mol

Chemical Properties

• CAS DataBase Reference: Methanesulfonic acid (R)-1-(4-methanesulfonyl-phenyl)-ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Methanesulfonic acid (R)-1-(4-methanesulfonyl-phenyl)-ethyl ester(726192-09-2)
• EPA Substance Registry System: Methanesulfonic acid (R)-1-(4-methanesulfonyl-phenyl)-ethyl ester(726192-09-2)

Safety Data

• Hazardous Substances Data: 726192-09-2(Hazardous Substances Data)

Upstream product

• 10297-73-1 4-(methanesulfonyl)acetophenone 
• 124-63-0 methanesulfonyl chloride 
• 726192-01-4 (R)-1-(4-(methylsulfonyl)phenyl)ethan-1-ol 

Downstream Products

• 726192-98-9 4-{(S)-4-[(S)-1-(4-Methanesulfonyl-phenyl)-ethyl]-3-methyl-piperazin-1-yl}-4-methyl-piperidine-1-carboxylic acid tert-butyl ester 
• 726192-95-6 (S)-4-[(S)-1-(4-Methanesulfonyl-phenyl)-ethyl]-3-methyl-piperazine-1-carboxylic acid tert-butyl ester 

Relevant articles and documents

Piperazine-based CCR5 antagonists as HIV-1 inhibitors. II. Discovery of 1-[(2,4-dimethyl-3-pyridinyl)carbonyl]-4methyl-4-[3(S)-methyl-4-[1(S)-[4- (trifluoromethyl) phenyl]ethyl]-1-piperazinyl]piperidine N1-oxide (Sch-350634), an orally bioavailable, poten

Truncation of the original piperidino-2(S)-methyl piperazine lead structure 2, from a family of muscarinic antagonists, gave compound 8 which has improved selectivity for the HIV-1 co-receptor CCR5 over muscarinic receptors. Further optimization for pharm

Piperazine derivatives useful as CCR5 antagonists

The use of CCR5 antagonists of the formula or a pharmaceutically acceptable salt thereof, wherein R is optionally substituted phenyl, pyridyl, thiophenyl or naphthyl; R1is hydrogen or alkyl; R2is substituted phenyl, substituted heter