Methanesulfonic acid (R)-1-(4-methanesulfonyl-phenyl)-ethyl ester

Base Information

• Chemical Name: Methanesulfonic acid (R)-1-(4-methanesulfonyl-phenyl)-ethyl ester
• CAS No.: 726192-09-2
• Molecular Formula: C₁₀H₁₄O₅S₂
• Molecular Weight: 278.35
• Mol file: 726192-09-2.mol

Synonyms:Methanesulfonic acid (R)-1-(4-methanesulfonyl-phenyl)-ethyl ester

Chemical Property of Methanesulfonic acid (R)-1-(4-methanesulfonyl-phenyl)-ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of Methanesulfonic acid (R)-1-(4-methanesulfonyl-phenyl)-ethyl ester

There total 2 articles about Methanesulfonic acid (R)-1-(4-methanesulfonyl-phenyl)-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methanesulfonyl chloride (124-63-0) + (R)-1-(4-(methylsulfonyl)phenyl)ethan-1-ol (726192-01-4) → Methanesulfonic acid (R)-1-(4-methanesulfonyl-phenyl)-ethyl ester (726192-09-2)

Guidance literature:

With triethylamine;

DOI:10.1021/jm0155401

Reference yield:

4-(methanesulfonyl)acetophenone (10297-73-1) → Methanesulfonic acid (R)-1-(4-methanesulfonyl-phenyl)-ethyl ester (726192-09-2)

Guidance literature:

Multi-step reaction with 2 steps

1: BH₃*SMe₂; chiral deriv. of oxazaboralodinone

2: Et₃N

With dimethylsulfide borane complex; chiral deriv. of oxazaboralodinone; triethylamine;

DOI:10.1021/jm0155401

Reference yield:

(S)-3-methyl-piperazine-1-carboxylic acid tert-butyl ester (147081-29-6) + Methanesulfonic acid (R)-1-(4-methanesulfonyl-phenyl)-ethyl ester (726192-09-2) → (S)-4-[(R)-1-(4-Methanesulfonyl-phenyl)-ethyl]-3-methyl-piperazine-1-carboxylic acid tert-butyl ester + (S)-4-[(S)-1-(4-Methanesulfonyl-phenyl)-ethyl]-3-methyl-piperazine-1-carboxylic acid tert-butyl ester (726192-95-6)

Guidance literature:

With thymidine 5'-phosphate; In acetonitrile; Heating;

DOI:10.1021/jm0155401

upstream raw materials:

methanesulfonyl chloride

(R)-1-(4-(methylsulfonyl)phenyl)ethan-1-ol

4-(methanesulfonyl)acetophenone

Downstream raw materials:

(S)-4-[(S)-1-(4-Methanesulfonyl-phenyl)-ethyl]-3-methyl-piperazine-1-carboxylic acid tert-butyl ester

4-{(S)-4-[(S)-1-(4-Methanesulfonyl-phenyl)-ethyl]-3-methyl-piperazin-1-yl}-4-methyl-piperidine-1-carboxylic acid tert-butyl ester