72621-19-3Relevant articles and documents
BODIPY-based fluorescent probes for mitochondria-targeted cell imaging with superior brightness, low cytotoxicity and high photostability
Gao, Tao,He, Huan,Huang, Rong,Zheng, Mai,Wang, Fang-Fang,Hu, Yan-Jun,Jiang, Feng-Lei,Liu, Yi
, p. 530 - 535 (2017)
Two mitochondria-targeted fluorescent probes (TPP- and TEA-BODIPY) were rationally designed and easily synthesized. These probes can specifically stain mitochondria in living cells with superior brightness, low cytotoxicity and high photostability, thus a
New BODIPYs for photodynamic therapy (PDT): Synthesis and activity on human cancer cell lines
Caruso, Enrico,Malacarne, Miryam C.,Marras, Emanuela,Papa, Ester,Bertato, Linda,Banfi, Stefano,Gariboldi, Marzia B.
, (2020)
A new class of compounds based on the 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene core, known as BODIPYs, has attracted significant attention as photosensitizers suitable for application in photodynamic therapy (PDT), which is a minimally invasive procedur
Efficient solution-processed deep-blue CIEy∈ (0.05) and pure-white CIEx,y∈ (0.34, 0.32) organic light-emitting diodes: experimental and theoretical investigation
Tagare, Jairam,Yadav, Rohit Ashok Kumar,Swayamprabha, Sujith Sudheendran,Dubey, Deepak Kumar,Jou, Jwo-Huei,Vaidyanathan, Sivakumar
, p. 4935 - 4947 (2021)
In this work, two bipolar non-conjugated deep-blue emitters, PICFOCz and BICFOCz, were synthesized by incorporating the charge transporting carbazole (donor/hole transporting) and imidazole (acceptor/electron-transporting) moietiesviaa flexible alkyl spac
Targeted fluorescence lifetime probes reveal responsive organelle viscosity and membrane fluidity
Steinmark, Ida Emilie,James, Arjuna L.,Chung, Pei-Hua,Morton, Penny E.,Parsons, Maddy,Dreiss, Cécile A.,Lorenz, Christian D.,Yahioglu, Gokhan,Suhling, Klaus
, (2019)
The only way to visually observe cellular viscosity, which can greatly influence biological reactions and has been linked to several human diseases, is through viscosity imaging. Imaging cellular viscosity has allowed the mapping of viscosity in cells, an
Effect of carbazole functionalization with a spacer moiety in the phenanthroimidazole bipolar ligand in a europium(iii) complex on its luminescence properties: combined experimental and theoretical study
Rajamouli, Boddula,Sivakumar, Vaidyanthan
, p. 1017 - 1027 (2017)
The functionalization of carbazole with a spacer in the C1 position and fluorine in the N1 position in the imidazole phenanthroline based bipolar ligand has been designed, synthesised and utilized to make a Eu(TTA)3Phen-Fl-O-CBZ complex. The ab
A bright, red-emitting water-soluble BODIPY fluorophore as an alternative to the commercial Mito Tracker Red for high-resolution mitochondrial imaging
Chen, Ji-Lei,Gao, Lian-Xun,Jiang, Feng-Lei,Liu, Yi,Wang, Jiang-Lin,Zhang, Lu,Zhou, Te
supporting information, p. 8639 - 8645 (2021/11/04)
With the emergence and rapid development of super-resolution fluorescence microscopy, monitoring of mitochondrial morphological changes has aroused great interest for exploring the role of mitochondria in the process of cell metabolism. However, in the absence of water-soluble, photostable and low-toxicity fluorescent dyes, ultra-high-resolution mitochondrial imaging is still challenging. Herein, we designed two fluorescent BODIPY dyes, namelyMito-BDP 630andMito-BDP 760, for mitochondrial imaging. The results proved thatMito-BDP 760underwent aggregation-caused quenching (ACQ) in the aqueous matrix owing to its hydrophobicity and was inaccessible to the cells, which restricted its applications in mitochondrial imaging. In stark contrast, water-solubleMito-BDP 630readily penetrated cellular and mitochondrial membranes for mitochondrial imaging with high dye densities under wash-free conditions as driven by membrane potential. As a comparison, Mito Tracker Red presented high photobleaching (the fluorescence intensity dropped by nearly 50%) and high phototoxicity after irradiation by a laser for 30 min. However,Mito-BDP 630possessed excellent biocompatibility, photostability and chemical stability. Furthermore, clear and bright mitochondria distribution in living HeLa cells after incubation withMito-BDP 630could be observed by CLSM. Convincingly, the morphology and cristae of mitochondria could be visualized using an ultra-high-resolution microscope. In short,Mito-BDP 630provided a powerful and convenient tool for monitoring mitochondrial morphologies in living cells. Given the facile synthesis, photobleaching resistance and low phototoxicity ofMito-BDP 630, it is an alternative to the commercial Mito Tracker Red.
Chelidamic acid derivatives: Precursors to functionalized pyridyl cryptands & functionalized metal ligands
Gibson, Harry W.,Nellipalli, Pothanagandhi,Niu, Zhenbin,Pederson, Adam M.-P.,Price, Terry L.
, (2021/07/21)
Pyridyl cryptands, such as 12–16 formed from pyridine-2,6-dicarbonyl chloride (4) and crown ether diols 7–11, have been demonstrated to be excellent hosts for viologens (N,N′-dialkyl-4,4′-bipyridinium salts, 2) with Ka values of ～104
Design, synthesis and evaluation of novel dimethylamino chalcone-O-alkylamines derivatives as potential multifunctional agents against Alzheimer's disease
Sang, Zhipei,Song, Qing,Cao, Zhongcheng,Deng, Yong,Tan, Zhenghuai,Zhang, Li
, (2021/03/04)
A novel series of dimethylamino chalcone-O-alkylamines derivatives was designed and synthesized as multifunctional agents for the treatment of AD. All the target compounds exhibited significant abilities to inhibit and disaggregate Aβ aggregation, and acted as potential selective AChE inhibitors, biometal chelators and selective MAO-B inhibitors. Among these compounds, compound TM-6 showed the greatest inhibitory activity against self-induced Aβ aggregation (IC50 = 0.88 μM) and well disaggregation ability toward self-induced Aβ aggregation (95.1%, 25 μM), the TEM images, molecular docking study and molecular dynamics simulations provided reasonable explanation for its high efficiency, and it was also found to be a remarkable antioxidant (ORAC-FL values of 2.1eq.), the best AChE inhibitor (IC50 = 0.13 μM) and MAO-B inhibitor (IC50 = 1.0 μM), as well as a good neuroprotectant. UV–visual spectrometry and ThT fluorescence assay revealed that compound TM-6 was not only a good biometal chelator by inhibiting Cu2+-induced Aβ aggregation (95.3%, 25 μM) but also could disassemble the well-structured Aβ fibrils (88.1%, 25 μM). Further, TM-6 could cross the blood-brain barrier (BBB) in vitro. More importantly, compound TM-6 did not show any acute toxicity in mice at doses of up to 1000 mg/kg and improved scopolamine-induced memory impairment. Taken together, these data indicated that TM-6, an excellent balanced multifunctional inhibitor, was a potential lead compound for the treatment of AD.
Novel imidazole-alkyl spacer-carbazole based fluorophores for deep-blue organic light emitting diodes: Experimental and theoretical investigation
Boddula, Rajamouli,Dubey, Deepak Kumar,Jou, Jwo-Huei,Patel, Sabita,Tagare, Jairam,Vaidyanathan, Sivakumar,Yadav, Rohit Ashok Kumar
, (2020/10/20)
A series of fluorescent emitters based on Imidazole-Alkyl spacer-Carbazole were designed and synthesized by connecting donor and acceptor moieties through alkyl spacer. In these design strategy we have chosen carbazole as electron rich and imidazole as electron deficient with deferent functional black (phenyl and phenyl substituted) at the N1 position of imidazole moiety. All the fluorophores were structurally confirmed by spectroscopic methods (NMR, MASS, and FTIR). The photophysical, electrochemical and electroluminescence properties were thoroughlyexamined. All the fluorophores showed good thermal stability and near-UV emission with high photoluminescence quantum yield (PLQY)of ~59% in the solid state. All the synthesized compounds feature Commission International de L'Eclairage (CIE) coordinates of y 0.08 for a particular doping concentration, which is very close to the National Television Standards Committee (NTSC) standard blue (0.14, 0.08). Solution-processed organic light emitting diode (OLED) device consisting of molecule BIPOCz displays a maximum external quantum efficiency EQE of 1.9% with CIE coordinates of (0.17, 0.07). All these results reveal that this work provides novel approaches for realizing ultra-deep-blue emission with high performance.
Tailoring the Solid-State Fluorescence of BODIPY by Supramolecular Assembly with Polyoxometalates
Bolle, Patricia,Benali, Tarik,Menet, Clotilde,Puget, Marin,Faulques, Eric,Marrot, Jér?me,Mialane, Pierre,Dolbecq, Anne,Serier-Brault, Hélène,Oms, Olivier,Dessapt, Rémi
supporting information, p. 12602 - 12609 (2021/08/24)
A cationic boron dipyrromethene (BODIPY) derivative (1+) has been successfully combined with two polyoxometalates (POMs), the Lindqvist-type [W6O19]2- and the β-[Mo8O26]4- units, into three new supramolecular fluorescent materials (1)2[W6O19]·2CH3CN, (1)2
