913380-95-7Relevant academic research and scientific papers
Synthesis of 4-[(diethylamino)methyl]-phenol derivatives as novel cholinesterase inhibitors with selectivity towards butyrylcholinesterase
Yu, Liang,Cao, Rihui,Yi, Wei,Yan, Qin,Chen, Zhiyong,Ma, Lin,Peng, Wenlie,Song, Huacan
experimental part, p. 3254 - 3258 (2010/09/04)
A series of novel cholinesterase inhibitors, being composed of 4-[(diethylamino)methyl]-phenoxy and secondary amine which were linked with a different length alkyl chain, were designed and synthesized from the starting material p-hydroxybenzaldehyde. Thes
Design, synthesis and evaluation of galanthamine derivatives as acetylcholinesterase inhibitors
Jia, Ping,Sheng, Rong,Zhang, Jing,Fang, Liang,He, Qiaojun,Yang, Bo,Hu, Yongzhou
experimental part, p. 772 - 784 (2009/09/05)
A new series of galanthamine derivatives have been designed, synthesized and evaluated as acetylcholinesterase inhibitors. All of the new compounds prepared showed high AChE inhibitory activities, with compound 3e that has an N-hexyl-benzyl piperidine substituent on the nitrogen atom reaching the best inhibitory activity for AChE (IC50 = 5.62 nM). The docking study performed with AutoDock demonstrated that 3e was nicely accommodated by AChE.
