72622-61-8

Upstream product

• 186581-53-3 diazomethane 
• 150715-15-4 (2E,3E)-3-(methoxycarbonyl)-2-((benzo[d][1,3]-dioxol-6-yl)methylene)-4-(3,4-dimethoxyphenyl)but-3-enoic acid 
• 78647-52-6 (+/-)-4-(3,4-dimethoxyphenyl)-3-methoxycarbonylbutanoic acid 
• 120-57-0 piperonal 
• 70381-89-4 methyl hydrogen (E)-2-<3,4-(methylenedioxy)benzylidene>succinate 
• 120-14-9 3,4-dimethoxy-benzaldehyde 
• 91364-70-4 dimethyl (E)-2-[benzo(d)(1,3)dioxol-5-ylmethylene]succinate 
• 78647-54-8 (3S,4R)-3-(Benzo[1,3]dioxol-5-yl-hydroxy-methyl)-4-(3,4-dimethoxy-benzyl)-dihydro-furan-2-one 
• 144539-74-2 3-(Benzo[1,3]dioxol-5-yl-hydroxy-methyl)-4-(3,4-dimethoxy-benzyl)-dihydro-furan-2-one 
• 78647-51-5 4-[3,4-dimethoxyphenyl]-3-(methoxycarbonyl)-3-butenoic acid 
• 72430-92-3 4-[(3,4-dimethoxyphenyl)methyl]dihydrofuran-2-one 

Downstream Products

• 18884-25-8 (3R^*,4R^*)-3-<3,4-(methylenedioxy)benzyl>-4-(3,4-dimethoxybenzyl)-γ-butyrolactone 
• 42923-60-4 2,3-bis-(hydroxymethyl)-6,7-methylenedioxy-1-(3',4'-dimethoxyphenyl)-naphthalene 
• 131318-40-6 (3S^*,4R^*)-3-methyl-3-<3,4-(methylenedioxy)benzyl>-4-(3,4-dimethoxybenzyl)-γ-butyrolactone 
• 5707-96-0 retrochinensin 
• 118040-42-9 Prasanthaline 
• 94285-09-3 lignan diol 

Relevant academic research and scientific papers

Efficient synthesis of lactonic and thionolactoniclignans and evaluation of their anti-oxidant, anti-inflammatory and cytotoxic activities

A short and versatile synthesis of α,β-dibenzyl-γ-butyrolactones has been developed starting from inexpensive materials by applying Stobbe condensation and following the novel reductive cyclisation with sodiumborohydride. Natural products Suchilactone (5a

Stereoselective syntheses of cis- and trans-isomers of α-hydroxy-α,β-dibenzyl-γ-butyrolactone lignans: New syntheses of (±)-trachelogenin and (±)-guayadequiol

Cis- and trans-isomers of α-hydroxy-α,β-dibenzyl-γ-butyrolactone lignans 1a,d-g and 2a,c,d were stereoselectively synthesized in good yields based on the electrophilic addition to the metal enolate of α-benzyl-γ-butyrolactone derivatives 1l-o and 3 as a key step. This method was applied to the syntheses of (±)-trachelogenin and (±)-guayadequiol, representative examples of the trans- and cis-isomers of α-hydroxy-α,β-dibenzyl-γ-butyrolactone lignan series.

Simple synthesis of trans-α,β-dibenzyl-γ-butyrolactone lignans by diastereoselective reduction of α-benzylidene-β-benzyl-γ-butyralactones using NaBH4-NiCl2

trans-α,β-Dibenzyl-γ-butyrolactone lignans were synthesized by stereoselective reduction of α-benzylidene-β-benzyl-γ-butyrolactones using NaBH4-NiCl2. The reduction is found to proceed via conjugate addition of a hydride to an α-benz

LIGNANS, BIFLAVONES AND TAXOIDS FROM HIMALAYAN TAXUS BACCATA

Chemical investigation of the twigs (separated from the needles) of the Himalayan yew, Taxus baccata, has culminated in the isolation of a new lignan, 4'-O-demethylsuchilactone, along with eight phenolic compounds, (-)-rhododendrol, (-)-rhododendrin, sciadopytisin, ginkgetin, kayaflavone, (-)-secoisolariciresinol, suchilactone and a lignan diol, not previously encountered in nature.Three taxoids, brevifoliol, 13-decinnamoyltaxchinin B and 10-deacetylbaccatin III were also isolated.This is the first report on the phytoconstituents isolated only fom the twigs of the Himalayan yew. - Key words: Taxus baccata; Taxaceae; twigs; phenolics; biflavones; lignans; taxoids; 4'-O-demethylsuchilactone.

A convenient total synthesis of (+/-)-jatrophan and 2,3-bis-(hydroxymethyl)-6,7-methylenedioxy-1-(3',4'-dimethoxyphenyl)naphthalene, lignan constituents of Jatropha gossypifolia Linn.

Convenient synthetic routes to (+/-)-jatrophan and 2,3-bis-(hydroxymethyl)-6,7-methylenedioxy-1-(3',4'-dimethoxyphenyl)naphthalene; the constituents of Jatropha gossypifolia Linn. have been reported.Stobbe condensation of piperonal with dimethyl succinate followed by methylation affords 4-(3',4'-methylenedioxyphenyl)-3-methoxy-carbonyl-methylbut-3-enoate.A second Stobbe condensation with veratraldehyde followed by Bouveault-Blanc reduction affords (+/-)-jatrophan.The aryl naphthalene lignan, 2,3-bis-(hydroxymethyl)-6,7-methylenedioxy-1-(3',4'-dimethoxyphenyl)naphthalene, has been synthesised from jatrophan by oxidative cyclisation followed by lithium aluminum hydride reduction.