72676-83-6

Upstream product

• 110-89-4 piperidine 
• 141-97-9 ethyl acetoacetate 
• 93-02-7 2,5-dimethoxybenzaldehyde 
• 144-55-8 sodium hydrogencarbonate 
• 72676-82-5 ethyl α-(2,5-dimethoxybenzylidene)acetoacetate 

Downstream Products

• 72676-84-7 2,4-diamino-5-methyl-6-(2,5-dimethoxybenzyl)-7-oxo-7,8-dihydropyrido[2,3-d ]pyrimidine 
• 170946-05-1 4-(2,5-Dimethoxyphenyl)-3-(hydroxymethyl)butan-2-ol 
• 72676-85-8 2,4-diamino-5-methyl-6-(2,5-dimethoxybenzyl)-7-chloro-pyrido[2,3-d]pyrimidine 
• 72732-56-0 piritrexim 

Relevant academic research and scientific papers

A tetrahydronaphthalene compound and its synthesis method

The invention belongs to the field of chemical synthesis, relates to a multi-substituted tetrahydronaphthalenes compound I, and the use thereof for preparing an important intermediate ammonia supple ratio star 2-acetyl-2-amino -5,8-dimethoxy -1, 2, 3, 4-t

2,4-diamino-5,6-disubstituted- and 5,6,7-trisubstituted 5-deazapteridines as insecticides

An insecticidal composition comprising, in admixture with an agriculturally acceptable carrier, an insecticidally effective amount of a 5-deazapteridine compound of the formula: STR1 wherein R1, R2, R3, R4, U, V, and W are as defined herein; agriculturally acceptable salts thereof; methods for using the same; and certain novel 5-deazapteridines per se.

Medicaments for the treatment of rheumatoid arthritis

A method of treatment of rheumatoid arthritis in humans in need thereof which comprises administering to said human an effective rheumatoid arthritis treatment amount of compound 2,4-diamino-6-(2,5-dimethoxybenzyl)--5-methylpyrido[2,3-d]pyrimidine or pharmaceutically acceptable acid addition salt thereof.

Treatment with dialkoxy pyridopyrimidines

Potent psoriasis activity in combination with low inhibition of histamine N-methyltransferase has been found in a class of 2,4-diamino-6-(2,5-dialkoxybenzyl)-5-methylpyrido[2,3-d]pyrimidines.

Synthesis and Antitumor Activity of 2,4-Diamino-6-(2,5-dimethoxybenzyl)-5-methylpyridopyrimidine

The synthesis of 2,4-diamino-6-(2,5-dimethoxybenzyl)-5-methylpyridopyrimidine (BW301U, 7) by a route that has general applicability to the preparation of many 6-(substituted benzyl)-5-methylpyridopyrimidines is described.The key intermediate, 2,4-diamino-7,8-dihydro-6-(2,5-dimethoxybenzyl)-5-methyl-7-oxopyridopyrimidine (4), is converted to the 7-chloro compound 5 by treatment with a 1:1 complex of N,N-dimethylformamide-thionyl chloride, and 5 is hydrogenolyzed with palladium on charcoal in the presence of potassium hydroxide to yield 7.BW301U is a potent lipid-soluble inhibitor of mammalian dihydrofolate reductase and has significant activity against the Walker 256 carcinosarcoma in rats.