72676-85-8

Upstream product

• 72676-84-7 2,4-diamino-5-methyl-6-(2,5-dimethoxybenzyl)-7-oxo-7,8-dihydropyrido[2,3-d ]pyrimidine 
• 72676-83-6 ethyl α-acetyl-β-(2,5-dimethoxyphenyl)propionate 
• 72676-82-5 ethyl α-(2,5-dimethoxybenzylidene)acetoacetate 
• 93-02-7 2,5-dimethoxybenzaldehyde 

Downstream Products

• 72732-56-0 piritrexim 

Relevant academic research and scientific papers

Treatment with dialkoxy pyridopyrimidines

Potent psoriasis activity in combination with low inhibition of histamine N-methyltransferase has been found in a class of 2,4-diamino-6-(2,5-dialkoxybenzyl)-5-methylpyrido[2,3-d]pyrimidines.

Synthesis and Antitumor Activity of 2,4-Diamino-6-(2,5-dimethoxybenzyl)-5-methylpyridopyrimidine

The synthesis of 2,4-diamino-6-(2,5-dimethoxybenzyl)-5-methylpyridopyrimidine (BW301U, 7) by a route that has general applicability to the preparation of many 6-(substituted benzyl)-5-methylpyridopyrimidines is described.The key intermediate, 2,4-diamino-7,8-dihydro-6-(2,5-dimethoxybenzyl)-5-methyl-7-oxopyridopyrimidine (4), is converted to the 7-chloro compound 5 by treatment with a 1:1 complex of N,N-dimethylformamide-thionyl chloride, and 5 is hydrogenolyzed with palladium on charcoal in the presence of potassium hydroxide to yield 7.BW301U is a potent lipid-soluble inhibitor of mammalian dihydrofolate reductase and has significant activity against the Walker 256 carcinosarcoma in rats.