72680-77-4Relevant articles and documents
The synthesis of α-amino-substituted diphenylphosphine oxides
Broekhof, N. L. J. M.,Elburg, P. van,Gen, A. van der
, p. 312 - 316 (2007/10/02)
Four methods with differing but overlapping specificity are described for the synthesis of α-unsubstituted as well as α-substituted (aminomethyl)diphenylphosphine oxides.The first method is based on the Arbusov reaction, the second on a Mannich-type condensation of diphenylphosphine oxide with aldehydes and secondary amines, the third on the addition of Ph2P(O)H to enamines and the fourth on the reaction of anions derived from α-unsubstituted (aminomethyl)diphenylphosphine oxides with various electrophiles.