72696-92-5

Basic information

• Product Name: Phosphonic acid, [2-[(phenylmethyl)amino]ethyl]-
• Synonyms: Phosphonic acid,[2-[(phenylmethyl)amino]ethyl];acide N-benzylamino-2 ethylphosphonique
• CAS NO: 72696-92-5
• Molecular Formula: C9H14NO3P
• Molecular Weight: 215.189
• Mol File: 72696-92-5.mol
• Article Data: 3

Chemical Properties

• Melting Point: >260 °C
• Boiling Point: 417.8±47.0 °C(Predicted)
• Density: 1.290±0.06 g/cm3(Predicted)
• CAS DataBase Reference: Phosphonic acid, [2-[(phenylmethyl)amino]ethyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Phosphonic acid, [2-[(phenylmethyl)amino]ethyl]-(72696-92-5)
• EPA Substance Registry System: Phosphonic acid, [2-[(phenylmethyl)amino]ethyl]-(72696-92-5)

Safety Data

• Hazardous Substances Data: 72696-92-5(Hazardous Substances Data)

Upstream product

• 1415210-80-8 C₁₅H₃₀NO₃PSi₂ 
• 100-39-0 benzyl bromide 
• 100-46-9 benzylamine 
• 16672-87-0 2-chloroethylphosphonic acid 
• 72696-77-6 {2-[Benzyl-(diethoxy-phosphoryl)-amino]-ethyl}-phosphonic acid diethyl ester 
• 79782-58-4 β-(N-benzyl)aminoethylphosphonic acid diethyl ester 

Downstream Products

• 2041-14-7 (2-aminethyl)phosphonic acid 

Relevant articles and documents

Synthesis of 2-(arylamino)ethyl phosphonic acids via the aza-Michael addition on diethyl vinylphosphonate

A simple way of synthesising 2-(arylamino)ethyl phosphonic esters and acids via the aza-Michael addition of amines to diethyl vinylphoshonate 'on water' was developed. Various 2-(arylamino)ethyl phosphonates were initially produced through the condensation of primary and secondary amines with diethyl vinylphosphonate, focussing on those bearing one aromatic moiety, giving generally good to high yields (i.e.; 75-100%). These phosphonic esters were then hydrolysed in presence of bromomethylsilane to give quantitatively the corresponding phosphonic acids.

Aminobenzylation d'aldehydes phosphoniques: preparation d'acides aminoalkylphosphoniques

The reaction of phosphonic aldehydes with benzylamine in presence of NaBH3CN yields benzylaminoalkylphosphonates which, submitted to catalytic hydrogenation, lead to phosphonic amino esters.When reductive amination is carried out with H2/Pd reduction and debenzylation are observed simultaneously.In the absence of reducing agent the enaminobenzylphosphonate can be isolated and N-alkylated.Hydrolysis of phosphonic amino-esters with dilute HCl gives phosphonic amino acids.The order of occurence of each operation, as well as the choice of the catalyst is discussed.