727-26-4

Basic information

• Product Name: [(4-chlorophenyl)sulfonyl][(trifluoromethyl)sulfonyl]methane
• CAS NO: 727-26-4
• Molecular Weight: 322.713
• Mol File: 727-26-4.mol

Chemical Properties

• CAS DataBase Reference: [(4-chlorophenyl)sulfonyl][(trifluoromethyl)sulfonyl]methane(CAS DataBase Reference)
• NIST Chemistry Reference: [(4-chlorophenyl)sulfonyl][(trifluoromethyl)sulfonyl]methane(727-26-4)
• EPA Substance Registry System: [(4-chlorophenyl)sulfonyl][(trifluoromethyl)sulfonyl]methane(727-26-4)

Safety Data

• Hazardous Substances Data: 727-26-4(Hazardous Substances Data)

Upstream product

• 714-17-0 4-Chlor-1-trifluormethylmercaptomethylmercapto-benzol 
• 106-54-7 p-Chlorothiophenol 
• 37595-74-7 N,N-phenylbistrifluoromethane-sulfonimide 
• 98-57-7 4-chlorophenyl methyl sulfone 
• 7205-90-5 chloromethyl 4-chlorophenyl sulfide 
• 35896-42-5 silver trifluoromethanesulfinate 

Downstream Products

• 1893-59-0 Trifluormethylsulfon-<3-nitro-4-(4-ethoxy-anilino)-phenylsulfon>-methan 
• 1584-83-4 Trifluormethylsulfon-<3-nitro-4-(4-methoxy-anilino)-phenylsulfon>-methan 
• 748-21-0 Trifluormethylsulfon-<3-nitro-4-anilino-phenylsulfon>-methan 
• 902-49-8 Trifluormethylsulfon-<3-nitro-4-ethylamino-phenylsulfon>-methan 
• 92015-08-2 Trifluormethylsulfon-(3-amino-4-ethylamino-phenylsulfon)-methan 
• 649-43-4 [(3-nitro-4-chlorophenyl)sulfonyl][(trifluoromethyl)sulfonyl]methane 

Relevant articles and documents

Synthesis and endectocidal activity of novel 1-(Arylsulfonyl)-1- [(trifluoromethyl)sulfonyl]methane derivatives

We have recently synthesized a series of novel disulfonylmethane compounds that have shown anthelmintic and insecticidal (endectocidal) activity. Several analogues have shown activity against the internal nematode Haemonchus contortus. In sheep studies, these analogues have shown 100% control of this internal parasite at a 10 mg/kg rate. In vitro activity against the biting flies, Stomoxys calcitrans and Haematobia irritans, has been observed at rates as low as 25 and 2.3 ppm, respectively. Only marginal activity against the liver fluke Fasciola hepatica and Trichostrongylus colubriformis was seen. Respiratory control index values on rat liver mitochondria for this series suggested uncoupling of oxidative phosphorylation as a mechanism of action. Compound 1 is considered to be a promising agent for treatment of parasitized sheep.

Use of disulfonyl methanes for the control of parasites

The present invention is directed to the use of disulfonyl methane compounds for the control of parasites in vertebrate animals.