727-45-7

Basic information

• Product Name: 11b-methyl-5,6,11,11b-tetrahydro-1H-indolizino[8,7-b]indol-3(2H)-one
• CAS NO: 727-45-7
• Molecular Weight: 240.305
• Mol File: 727-45-7.mol
• Article Data: 11

Chemical Properties

• CAS DataBase Reference: 11b-methyl-5,6,11,11b-tetrahydro-1H-indolizino[8,7-b]indol-3(2H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 11b-methyl-5,6,11,11b-tetrahydro-1H-indolizino[8,7-b]indol-3(2H)-one(727-45-7)
• EPA Substance Registry System: 11b-methyl-5,6,11,11b-tetrahydro-1H-indolizino[8,7-b]indol-3(2H)-one(727-45-7)

Safety Data

• Hazardous Substances Data: 727-45-7(Hazardous Substances Data)

Usage

Chemical class

Indolizinoindole This compound belongs to a class of organic compounds characterized by a fused indole and pyrrolidine ring systems.

Molecular structure

Complex carbon ring with nitrogen atoms The compound features a complex arrangement of carbon and nitrogen atoms in its molecular structure.

Potential biological activity

Unknown The compound may have potential biological activity, but further scientific studies are required to determine its specific effects.

Pharmacological and medicinal research

Of interest The compound is of interest for various pharmacological and medicinal research purposes due to its unique structure and potential biological activity.

Specific properties

Dependent on further studies The specific properties and potential applications of this compound would depend on the results of further scientific studies and investigations.

Stereochemistry

Tetrahydro The compound has a tetrahydro (four hydrogen atoms) substitution in its structure, which may influence its properties and potential applications.

Functional groups

Indolizine and indole rings The compound contains both indolizine and indole ring systems, which are common in various biologically active compounds.

Solubility

Unknown The solubility of the compound in different solvents is not provided in the material and would require further investigation.

Stability

Unknown The stability of the compound under various conditions (e.g., temperature, pH, light exposure) is not provided and would require further study.

Synthesis

Not provided The synthesis method for this compound is not mentioned in the material, and further information would be needed to understand its preparation.

Applications

Not specified The specific applications of this compound are not provided in the material, but its unique structure and potential biological activity suggest it may have uses in the pharmaceutical or chemical industries.

Upstream product

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Relevant articles and documents

Diverse synthesis of natural product inspired fused and spiro-heterocyclic scaffolds via ring distortion and ring construction strategies

Several natural product inspired fused and spiro-heterocyclic scaffolds were prepared by ring distortion and ring construction strategies and evaluated for anti-breast cancer activity. A facile domino Pictet-Spengler lactamization (PSL) afforded nine natural product inspired indolo[2,3-a]quinolizidine and indolo[8,7-b]indolizidine scaffolds which are converted to seven other scaffolds by functional group transformation, ring distortion and ring construction strategies. In vitro screenings of this library of sixteen scaffolds with six distinct architectures against MCF7 cell lines afforded two compounds (10 and 21) with modest activity. Principal component analysis of this library against databases of FDA approved drugs, commercial compounds and FDA approved breast cancer compounds indicated an eclectic mix of structures among the molecules.

Racemic and diastereoselective construction of indole alkaloids under solvent- and catalyst-free microwave-assisted Pictet-Spengler condensation

An environment-friendly high-yielding method for the racemic and asymmetric diastereoselective preparation of indole alkaloids via Pictet-Spengler reaction is reported. The reaction proceeds with short reaction times under solvent-free and microwave-irrad

Gold-catalyzed Rapid Construction of Nitrogen-containing Heterocyclic Compound Library with Scaffold Diversity and Molecular Complexity

1,3-unsubstituted 2-(1H-indol-2-yl)ethanamines were employed for the first time to react with alkynoic acids (AAs) to achieve gold-catalyzed highly selective cascade reactions to furnish novel indole-fused skeletons. Furthermore, with this powerful gold catalytic system, a library of indole/pyrrole/thiophene/benzene/naphthalene/pyridine-based nitrogen-containing heterocyclic compounds (NCHCs) with scaffold diversity and molecular complexity was constructed rapidly using various amine nucleophiles (ANs) and diverse AAs as the building blocks. This general protocol features excellent selectivity, extraordinarily broad substrate scope, readily available inputs, good to high yields, high bond-forming efficiency, and step economy, thus providing a facile and efficient access to a variety of valuable nitrogen-containing heterocycles.