727-74-2Relevant academic research and scientific papers
Quinoline-4-methyl esters as human nonpancreatic secretory phospholipase A2 inhibitors
Wu, Yiran,Chen, Zheng,Liu, Ying,Yu, Lanlan,Zhou, Lu,Yang, Suijia,Lai, Luhua
experimental part, p. 3361 - 3366 (2011/07/29)
A series of novel fused heterocycle methyl esters were designed and synthesized as human nonpancreatic secretory phospholipase A2 (hnps-PLA2) competitive inhibitors. Among the 22 synthesized compounds, 17 quinoline-4-methyl esters displayed hnps-PLA2 inhibition activity in the in vitro bioassay. The IC50 value for the best compound 3o was 1.5 μM. The structure-inhibition-activity relationships of the compounds were studied using molecular docking.
