351-09-7

Basic information

• Product Name: 4-FLUOROISONITROSOACETANILIDE
• Synonyms: 4'-FLUOROISONITROSOACETANILIDE;4-FLUOROISONITROSOACETANILIDE;4'-Fluoroisonitrosoacetanilide 99%;4'-Fluoroisonitrosoacetanilide99%;4-Fluoro-N-{[(hydroxyimino)methyl]carbonyl}aniline;N-(4-Fluorophenyl)-2-(hydroxyimino)acetamide 99%;(E)-N-(4-fluorophenyl)-2-(hydroxyiMino)acetaMide
• CAS NO: 351-09-7
• Molecular Formula: C₈H₇FN₂O₂
• Molecular Weight: 182.15
• Product Categories: chiral
• Mol File: 351-09-7.mol
• Article Data: 36

Chemical Properties

• Melting Point: 162
• Appearance: /
• Density: 1.3 g/cm³
• Refractive Index: 1.55
• PKA: 8.77±0.10(Predicted)
• CAS DataBase Reference: 4-FLUOROISONITROSOACETANILIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-FLUOROISONITROSOACETANILIDE(351-09-7)
• EPA Substance Registry System: 4-FLUOROISONITROSOACETANILIDE(351-09-7)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 351-09-7(Hazardous Substances Data)

Usage

General Description

4-Fluoroisonitrosoacetanilide is a chemical compound with the molecular formula C8H8FN2O2. It is an aromatic amine derivative and contains a fluoro substituent on the phenyl ring. 4-Fluoroisonitrosoacetanilide is a nitroso compound, which means it contains the nitroso functional group (-N=O). 4-Fluoroisonitrosoacetanilide is commonly used as a reagent in organic synthesis and pharmaceutical research. It has potential applications in the development of new drugs and agrochemicals. However, it is important to handle this chemical with caution as it may have hazardous properties.

InChI:InChI=1/C8H7FN2O2/c9-6-1-3-7(4-2-6)11-8(12)5-10-13/h1-5,13H,(H,11,12)/b10-5+

Upstream product

• 75-87-6 chloral 
• 371-40-4 4-fluoroaniline 
• 302-17-0 chloral hydrate 
• 2146-07-8 p-fluoroaniline hydrochloride 

Downstream Products

• 443-69-6 5-fluoro-1H-indole-2,3-dione 
• 861238-49-5 2-(3-chlorophenyl)-6-fluoroquinoline-4-carboxylic acid 
• 18060-42-9 6-fluoro-2-p-tolylquinoline-4-carboxylic acid 
• 897561-82-9 2-(2,4-dichlorophenyl)-6-fluoroquinoline-4-carboxylic acid 
• 1453173-04-0 C₁₆H₉ClFNO 
• 1453173-66-4 C₁₇H₁₁ClFNO₂ 
• 1453175-50-2 C₁₇H₁₁ClFNO₂ 
• 1453176-93-6 C₁₆H₈Cl₂FNO 
• 1453176-95-8 C₁₆H₈ClF₂NO 
• 1453176-99-2 C₁₇H₁₁ClFNO 

Relevant articles and documents

Study on synthesis of some substituted N-propargyl isatins by propargylation reaction of corresponding isatins using potassium carbonate as base under ultrasound- and microwave-assisted conditions

Substituted N-propargyl isatins were synthesized by SN2 reaction of corresponding substituted isatins with propargyl bromide in the presence of anhydrous K2CO3 as base. We reported about study on systematically synthesis of these compounds using heating procedures under different reaction conditions, including microwave-assisted heating conditions at power of 100?W (Procedure A), conventional heating conditions in water bath at 50?°C in acetonitrile (Procedure B), and conventional heating conditions in water bath at 50?°C in DMF (procedure C). The best procedure A was deduced based on the investigations on the reaction conditions. Almost all substituted N-propargyl isatins were new, except compounds with R of H, 5-Me, 5-Cl and 5-Br substituents. The structures of the obtained compounds were confirmed by the modern spectroscopic methods.

Synthesis and evaluation of tryptanthrins as antitumor agents

Here, an efficient and convenient method has been developed for the rapid preparation of N-substituted tryptanthrin analogues through the reaction of tryptanthrins and secondary amines under mild reaction conditions. All compounds were tested for their anti-tumor activity in cancer cell lines by MTT assay. The results showed that some of them exhibited anti-tumor activity against human tumor cell lines A549, HCT116, MDA-MB-231 with IC50 mean values at a low micromolar level. In particular, compound 3b induced G2/S cell cycle arrest and apoptosis in A549 cells dose-dependently.

Synthesis of substituted tryptanthrin via aryl halides and amines as antitumor and anti-MRSA agents

The natural alkaloid, tryptanthrin (indolo[2,1-b]quinazoline-6,12-dione), and its analogues are found to exhibit potent antitumor and anti-MRSA activities. An efficient and convenient method has been developed for the synthesis of tryptanthrin D-ring derivatives through the reaction of substituted tryptanthrins and secondary amines in moderate to good yields. Some of the new compounds exhibited antitumor activities against the human tumor cell lines A549, HCT116 and MDA-MB-231, with mean IC50 values at low micromolar levels. In addition, some of the compounds showed excellent anti-MRSA activities and were more effective than vancomycin, with MIC values of 0.31–1.25 μg/mL for Mu50,RN4220, and Newman strains.